論文 - 詳細
| RRC ID | 84152 |
|---|---|
| 著者 | Almoril-Porras A, Calvo AC, Niu L, Beagan J, Díaz García M, Hawk JD, Aljobeh A, Wisdom EM, Ren I, Wang ZW, Colón-Ramos DA. |
| タイトル | Configuration of electrical synapses filters sensory information to drive behavioral choices. |
| ジャーナル | Cell |
| Abstract |
Synaptic configurations underpin how the nervous system processes sensory information to produce a behavioral response. This is best understood for chemical synapses, and we know far less about how electrical synaptic configurations modulate sensory information processing and context-specific behaviors. We discovered that innexin 1 (INX-1), a gap junction protein that forms electrical synapses, is required to deploy context-specific behavioral strategies underlying thermotaxis behavior in C. elegans. Within this well-defined circuit, INX-1 couples two bilaterally symmetric interneurons to integrate sensory information during migratory behavior across temperature gradients. In inx-1 mutants, uncoupled interneurons display increased excitability and responses to subthreshold sensory stimuli due to increased membrane resistance and reduced membrane capacitance, resulting in abnormal responses that extend run durations and trap the animals in context-irrelevant tracking of isotherms. Thus, a conserved configuration of electrical synapses enables differential processing of sensory information to deploy context-specific behavioral strategies. |
| 巻・号 | 188(1) |
| ページ | 89-103.e13 |
| 公開日 | 2025-1-9 |
| DOI | 10.1016/j.cell.2024.11.037 |
| PII | S0092-8674(24)01378-3 |
| PMID | 39742807 |
| MeSH | Animals Behavior, Animal Caenorhabditis elegans* / metabolism Caenorhabditis elegans* / physiology Caenorhabditis elegans Proteins* / genetics Caenorhabditis elegans Proteins* / metabolism Connexins* / genetics Connexins* / metabolism Electrical Synapses* / metabolism Electrical Synapses* / physiology Gap Junctions / metabolism Interneurons / metabolism Interneurons / physiology Mutation Taxis Response / physiology |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 79 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm3424 tm3524 tmIs1091 |