論文 - 詳細
| RRC ID | 84207 |
|---|---|
| 著者 | Gordon SG, Rodriguez AA, Gu Y, Corbett KD, Lee CF, Rog O. |
| タイトル | The synaptonemal complex aligns meiotic chromosomes by wetting. |
| ジャーナル | Sci Adv |
| Abstract |
During meiosis, the parental chromosomes are drawn together to enable exchange of genetic information. Chromosomes are aligned through the assembly of a conserved interface, the synaptonemal complex, composed of a central region that forms between two parallel chromosomal backbones called axes. Here, we identify the axis-central region interface in C. elegans, containing a conserved positive patch on the axis component HIM-3 and the negative C terminus of the central region protein SYP-5. Crucially, the canonical ultrastructure of the synaptonemal complex is altered upon weakening this interface using charge-reversal mutations. We developed a thermodynamic model that recapitulates our experimental observations, indicating that the liquid-like central region can assemble by wetting the axes without active energy consumption. More broadly, our data show that condensation drives tightly regulated nuclear reorganization during sexual reproduction. |
| 巻・号 | 11(9) |
| ページ | eadt5675 |
| 公開日 | 2025-2-28 |
| DOI | 10.1126/sciadv.adt5675 |
| PMID | 40009663 |
| PMC | PMC11864179 |
| MeSH | Animals Caenorhabditis elegans* / genetics Caenorhabditis elegans* / metabolism Caenorhabditis elegans Proteins / chemistry Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Chromosomes* / genetics Chromosomes* / metabolism Meiosis* / genetics Mutation Synaptonemal Complex* / genetics Synaptonemal Complex* / metabolism |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 11 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm1857 tm3655 |