論文 - 詳細
| RRC ID | 84221 |
|---|---|
| 著者 | Li Y, Wang C, Fu X, Wu D, He C, Dai W, Yue X, Luo Z, Yang J, Wan QL. |
| タイトル | Transgenerational inheritance of mitochondrial hormetic oxidative stress mediated by histone H3K4me3 and H3K27me3 modifications. |
| ジャーナル | Redox Biol |
| Abstract |
Mitochondrial hormetic oxidative stress (mtHOS) is crucial in physiology and disease; however, its effects on epigenetic inheritance and organism fitness across generations remains elusive. Utilizing the C. elegans as a model, we elucidate that parental exposure to mtHOS not only elicits a lifespan extension in the exposed individuals but also confers this longevity advantage to the progeny through the transgenerational epigenetic inheritance (TEI) mechanism. This transgenerational transmission of lifespan prolongation depends on the activation of the UPRmt and the synergistic action of the transcription factors DAF-16/FOXO and SKN-1/Nrf2. Additionally, the H3K4me3 and H3K27me3 serve as epigenetic mediators, selectively marking and regulating the expression of genes associated with oxidative stress response and longevity determination. Our findings illuminate the mechanisms underlying the implementation and transmission of mtHOS, revealing a sophisticated interplay among oxidative stress response genes and chromatin remodeling that collectively enhances the progeny's adaptive resilience to future challenges. |
| 巻・号 | 82 |
| ページ | 103598 |
| 公開日 | 2025-5-1 |
| DOI | 10.1016/j.redox.2025.103598 |
| PII | S2213-2317(25)00111-9 |
| PMID | 40112613 |
| PMC | PMC11979432 |
| MeSH | Animals Caenorhabditis elegans* / genetics Caenorhabditis elegans* / metabolism Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism DNA-Binding Proteins Epigenesis, Genetic Forkhead Transcription Factors / genetics Forkhead Transcription Factors / metabolism Histones* / genetics Histones* / metabolism Hormesis* Longevity / genetics Mitochondria* / genetics Mitochondria* / metabolism Oxidative Stress* / genetics Transcription Factors / genetics Transcription Factors / metabolism |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.2 |
| リソース情報 | |
| 線虫 | tm4803 tm4919 |