Reference - Detail
| RRC ID | 85053 |
|---|---|
| Author | Hirata S, Havercamp K, Yamanashi Y, Udono T. |
| Title | Hepatitis C virus infection reduces the lifespan of chimpanzees used in biomedical research. |
| Journal | Biol Lett |
| Abstract |
Chimpanzees were used in hepatitis research for over three decades with the aim to identify and develop treatments for the virus, a leading cause of chronic liver disease in humans. We used a dataset of 120 chimpanzees housed at a single institution in Japan, 22 of whom became chronically infected with hepatitis C virus (HCV), to examine whether HCV infection results in a reduced lifespan as reported in humans. Survival analysis showed that HCV carriers experienced a higher mortality risk compared with non-carriers. Although no chimpanzee died from hepatic disease, carriers showed higher gamma-glutamyl transpeptidase (γGTP) levels compared with non-carriers suggesting that HCV infection negatively affected their liver condition. These results provide evidence that special attention is necessary to monitor the long-term condition of ex-biomedical primates. |
| Volume | 18(8) |
| Pages | 20220048 |
| Published | 2022-8-1 |
| DOI | 10.1098/rsbl.2022.0048 |
| PMID | 35946233 |
| PMC | PMC9364148 |
| MeSH | Animals Biomedical Research* Hepacivirus Hepatitis C* / veterinary Humans Longevity Pan troglodytes |
| IF | 2.869 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 15 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| GAIN | id=631 id=359 id=635 id=363 id=634 id=371 id=375 id=667# id=762# id=376 id=377 id=639 |