| RRC ID |
85053
|
| 著者 |
Hirata S, Havercamp K, Yamanashi Y, Udono T.
|
| タイトル |
Hepatitis C virus infection reduces the lifespan of chimpanzees used in biomedical research.
|
| ジャーナル |
Biol Lett
|
| Abstract |
Chimpanzees were used in hepatitis research for over three decades with the aim to identify and develop treatments for the virus, a leading cause of chronic liver disease in humans. We used a dataset of 120 chimpanzees housed at a single institution in Japan, 22 of whom became chronically infected with hepatitis C virus (HCV), to examine whether HCV infection results in a reduced lifespan as reported in humans. Survival analysis showed that HCV carriers experienced a higher mortality risk compared with non-carriers. Although no chimpanzee died from hepatic disease, carriers showed higher gamma-glutamyl transpeptidase (γGTP) levels compared with non-carriers suggesting that HCV infection negatively affected their liver condition. These results provide evidence that special attention is necessary to monitor the long-term condition of ex-biomedical primates.
|
| 巻・号 |
18(8)
|
| ページ |
20220048
|
| 公開日 |
2022-8-1
|
| DOI |
10.1098/rsbl.2022.0048
|
| PMID |
35946233
|
| PMC |
PMC9364148
|
| MeSH |
Animals
Biomedical Research*
Hepacivirus
Hepatitis C* / veterinary
Humans
Longevity
Pan troglodytes
|
| IF |
2.869
|
| リソース情報 |
| GAIN |
id=631
id=359
id=635
id=363
id=634
id=371
id=375
id=667#
id=762#
id=376
id=377
id=639 |
