論文 - 詳細
| RRC ID | 85211 |
|---|---|
| 著者 | Fukui H, Chow RW, Xie J, Foo YY, Yap CH, Minc N, Mochizuki N, Vermot J. |
| タイトル | Bioelectric signaling and the control of cardiac cell identity in response to mechanical forces. |
| ジャーナル | Science |
| Abstract |
Developing cardiovascular systems use mechanical forces to take shape, but how ubiquitous blood flow forces instruct local cardiac cell identity is still unclear. By manipulating mechanical forces in vivo, we show here that shear stress is necessary and sufficient to promote valvulogenesis. We found that valve formation is associated with the activation of an extracellular adenosine triphosphate (ATP)–dependent purinergic receptor pathway, specifically triggering calcium ion (Ca2+) pulses and nuclear factor of activated T cells 1 (Nfatc1) activation. Thus, mechanical forces are converted into discrete bioelectric signals by an ATP-Ca2+-Nfatc1–mechanosensitive pathway to generate positional information and control valve formation. |
| 巻・号 | 374(6565) |
| ページ | 351-354 |
| 公開日 | 2021-10-15 |
| DOI | 10.1126/science.abc6229 |
| PMID | 34648325 |
| MeSH | Adenosine Triphosphate / metabolism Animals Calcium / metabolism Calcium Signaling Electrophysiological Phenomena Endothelial Cells / physiology Heart Valves / cytology Heart Valves / growth & development* Heart Valves / metabolism NFATC Transcription Factors / metabolism Receptors, Purinergic P2 / metabolism Shear Strength* Stress, Mechanical* Zebrafish |
| IF | 41.846 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 172 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | UAS:RFP UAS:GCaMP7a |