Reference - Detail
| RRC ID | 85363 |
|---|---|
| Author | Michel L, Osypenko D, Molina P, Mutlu KA, Lecca S, Hisatsune C, Mikoshiba K, Kikuchi T, Yaksi E, Volterra A, Mameli M. |
| Title | Calcium dynamics in habenular astrocytes regulate active coping within behavioral transitions. |
| Journal | Commun Biol |
| Abstract |
Behavioral challenges prompt alternating vigorous and reduced mobility - active, passive coping - that optimize energy investment. Here, we show that disrupting astrocytes calcium signaling in the mouse lateral habenula (LHb) prolongs active coping. This state manifests through calcium elevations in both mouse and zebrafish habenular astrocytes. Presynaptic tracing approaches integrate LHb astrocytes within aversion-related neuronal circuits. Thus, astrocytes regulate state transitions highlighting their computational contribution to behaviors across species. |
| Volume | 8(1) |
| Pages | 1087 |
| Published | 2025-7-22 |
| DOI | 10.1038/s42003-025-08535-5 |
| PII | 10.1038/s42003-025-08535-5 |
| PMID | 40696163 |
| MeSH | Adaptation, Psychological* Animals Astrocytes* / metabolism Astrocytes* / physiology Behavior, Animal* / physiology Calcium* / metabolism Calcium Signaling* Habenula* / cytology Habenula* / metabolism Habenula* / physiology Male Mice Mice, Inbred C57BL Zebrafish |
| IF | 4.165 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Bluesky |
| Total number of mentions | 13 |
| Altmetric score changes over past 6months | 0.2 |
| Resource | |
| Mice | RBRC10292 |