| RRC ID |
85363
|
| Author |
Michel L, Osypenko D, Molina P, Mutlu KA, Lecca S, Hisatsune C, Mikoshiba K, Kikuchi T, Yaksi E, Volterra A, Mameli M.
|
| Title |
Calcium dynamics in habenular astrocytes regulate active coping within behavioral transitions.
|
| Journal |
Commun Biol
|
| Abstract |
Behavioral challenges prompt alternating vigorous and reduced mobility - active, passive coping - that optimize energy investment. Here, we show that disrupting astrocytes calcium signaling in the mouse lateral habenula (LHb) prolongs active coping. This state manifests through calcium elevations in both mouse and zebrafish habenular astrocytes. Presynaptic tracing approaches integrate LHb astrocytes within aversion-related neuronal circuits. Thus, astrocytes regulate state transitions highlighting their computational contribution to behaviors across species.
|
| Volume |
8(1)
|
| Pages |
1087
|
| Published |
2025-7-22
|
| DOI |
10.1038/s42003-025-08535-5
|
| PII |
10.1038/s42003-025-08535-5
|
| PMID |
40696163
|
| MeSH |
Adaptation, Psychological*
Animals
Astrocytes* / metabolism
Astrocytes* / physiology
Behavior, Animal* / physiology
Calcium* / metabolism
Calcium Signaling*
Habenula* / cytology
Habenula* / metabolism
Habenula* / physiology
Male
Mice
Mice, Inbred C57BL
Zebrafish
|
| IF |
4.165
|
| Resource |
| Mice |
RBRC10292 |
