論文 - 詳細
| RRC ID | 85363 |
|---|---|
| 著者 | Michel L, Osypenko D, Molina P, Mutlu KA, Lecca S, Hisatsune C, Mikoshiba K, Kikuchi T, Yaksi E, Volterra A, Mameli M. |
| タイトル | Calcium dynamics in habenular astrocytes regulate active coping within behavioral transitions. |
| ジャーナル | Commun Biol |
| Abstract |
Behavioral challenges prompt alternating vigorous and reduced mobility - active, passive coping - that optimize energy investment. Here, we show that disrupting astrocytes calcium signaling in the mouse lateral habenula (LHb) prolongs active coping. This state manifests through calcium elevations in both mouse and zebrafish habenular astrocytes. Presynaptic tracing approaches integrate LHb astrocytes within aversion-related neuronal circuits. Thus, astrocytes regulate state transitions highlighting their computational contribution to behaviors across species. |
| 巻・号 | 8(1) |
| ページ | 1087 |
| 公開日 | 2025-7-22 |
| DOI | 10.1038/s42003-025-08535-5 |
| PII | 10.1038/s42003-025-08535-5 |
| PMID | 40696163 |
| MeSH | Adaptation, Psychological* Animals Astrocytes* / metabolism Astrocytes* / physiology Behavior, Animal* / physiology Calcium* / metabolism Calcium Signaling* Habenula* / cytology Habenula* / metabolism Habenula* / physiology Male Mice Mice, Inbred C57BL Zebrafish |
| IF | 4.165 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 13 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.2 |
| リソース情報 | |
| 実験動物マウス | RBRC10292 |