Reference - Detail
| RRC ID | 85431 |
|---|---|
| Author | Dong A, Yoshizumi M, Kokubo H. |
| Title | Odz4 upregulates SAN-specific genes to promote differentiation into cardiac pacemaker-like cells. |
| Journal | FEBS Lett |
| Abstract |
Cardiac arrhythmias stemming from abnormal sinoatrial node (SAN) function can lead to sudden death. Developing a biological pacemaker device for treating sick sinus syndrome (SSS) could offer a potential cure. Understanding SAN differentiation is crucial, yet its regulatory mechanism remains unclear. We reanalyzed published RNA-seq data and identified Odz4 as a SAN-specific candidate. In situ hybridization revealed Odz4 expression in the cardiac crescent and throughout the cardiac conduction system (CCS). To assess the role of Odz4 in CCS differentiation, we utilized a Tet-Off inducible system for its intracellular domain (ICD). Embryonic bodies (EBs) exogenously expressing Odz4-ICD exhibited an increased propensity to develop into pacemaker-like cells with enhanced automaticity and upregulated expression of SAN-specific genes. CellChat and GO analyses unveiled SAN-specific enrichment of ligand-receptor sets, especially Ptn-Ncl, and extracellular matrix components in the group exogenously expressing Odz4-ICD. Our findings underscore the significance of Odz4 in SAN development and offer fresh insights into biological pacemaker establishment. |
| Volume | 599(3) |
| Pages | 299-315 |
| Published | 2025-2-1 |
| DOI | 10.1002/1873-3468.15036 |
| PMID | 39462648 |
| PMC | PMC11808419 |
| MeSH | Animals Cell Differentiation* / genetics Humans Mice Myocytes, Cardiac* / cytology Myocytes, Cardiac* / metabolism Sick Sinus Syndrome / genetics Sick Sinus Syndrome / metabolism Sinoatrial Node* / cytology Sinoatrial Node* / metabolism Up-Regulation |
| IF | 3.057 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Peer-review(Publons) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | COS-7(RCB0539) EBRTcH3(AES0054) |