論文 - 詳細
| RRC ID | 86729 |
|---|---|
| 著者 | Malchow J, Eberlein J, Li W, Hogan BM, Okuda KS, Helker CSM. |
| タイトル | Neural progenitor-derived Apelin controls tip cell behavior and vascular patterning. |
| ジャーナル | Sci Adv |
| Abstract |
During angiogenesis, vascular tip cells guide nascent vascular sprouts to form a vascular network. Apelin, an agonist of the G protein-coupled receptor Aplnr, is enriched in vascular tip cells, and it is hypothesized that vascular-derived Apelin regulates sprouting angiogenesis. We identify an apelin-expressing neural progenitor cell population in the dorsal neural tube. Vascular tip cells exhibit directed elongation and migration toward and along the apelin-expressing neural progenitor cells. Notably, restoration of neural but not vascular apelin expression in apelin mutants remedies the angiogenic defects of mutants. By functional analyses, we show the requirement of Apelin signaling for tip cell behaviors, like filopodia formation and cell elongation. Through genetic interaction studies and analysis of transgenic activity reporters, we identify Apelin signaling as a modulator of phosphoinositide 3-kinase and extracellular signal-regulated kinase signaling in tip cells in vivo. Our results suggest a previously unidentified neurovascular cross-talk mediated by Apelin signaling that is important for tip cell function during sprouting angiogenesis. |
| 巻・号 | 10(27) |
| ページ | eadk1174 |
| 公開日 | 2024-7-5 |
| DOI | 10.1126/sciadv.adk1174 |
| PMID | 38968355 |
| PMC | PMC11225789 |
| MeSH | Animals Apelin* / genetics Apelin* / metabolism Cell Movement Chemokines Intercellular Signaling Peptides and Proteins / genetics Intercellular Signaling Peptides and Proteins / metabolism Neovascularization, Physiologic* Neural Stem Cells* / cytology Neural Stem Cells* / metabolism Neural Tube / metabolism Phosphatidylinositol 3-Kinases / metabolism Signal Transduction* Zebrafish Zebrafish Proteins |
| IF | 13.117 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 52 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | UAS:RFP |