| RRC ID |
86
|
| Author |
Hiraoka-Yamamoto J, Nara Y, Yasui N, Onobayashi Y, Tsuchikura S, Ikeda K.
|
| Title |
Establishment of a new animal model of metabolic syndrome: SHRSP fatty (fa/fa) rats.
|
| Journal |
Clin Exp Pharmacol Physiol
|
| Abstract |
1. We established a new animal model of metabolic syndrome, SHRSP fatty (fa/fa) rats, by crossing stroke-prone spontaneously hypertensive rats of the Izumo strain (SHRSP/Izm) to Zucker fatty (ZF) (fa/fa) rats. 2. The SHRSP fatty (fa/fa) rats have a missense mutation of the leptin receptor gene and plasma leptin concentrations are augmented. The SHRSP fatty (fa/fa) rats develop obesity and hypertension simultaneously. 3. Plasma metabolic parameters, including glucose, insulin and total cholesterol and triglyceride levels, were markedly elevated in SHRSP fatty (fa/fa) rats compared with SHRSP/Izm rats. Plasma triglyceride concentrations in SHRSP fatty (fa/fa) rats were significantly elevated compared with those in ZF (fa/fa) rats. The weight of adipose tissues in SHRSP fatty (fa/fa) rats was greater than that of SHRSP/Izm rats. The phenotype of SHRSP fatty (fa/fa) rats is similar to that of human metabolic syndrome.
|
| Volume |
31(1-2)
|
| Pages |
107-9
|
| Published |
2004-1-1
|
| DOI |
10.1111/j.1440-1681.2004.03962.x
|
| PMID |
14756693
|
| MeSH |
Adipose Tissue / anatomy & histology
Animals
Blood Glucose / metabolism
Body Composition / physiology
Body Weight / physiology
Cardiovascular Diseases / etiology
Cardiovascular Diseases / genetics
Disease Models, Animal
Hemodynamics / genetics
Hemodynamics / physiology
Insulin / blood
Lipids / blood
Metabolic Syndrome / genetics
Metabolic Syndrome / physiopathology*
Mutation / physiology
Obesity / genetics
Phenotype
Rats
Rats, Inbred SHR
Rats, Zucker
Receptors, Cell Surface / genetics
Receptors, Leptin
|
| IF |
2.456
|
|
WOS Category
|
PHARMACOLOGY & PHARMACY
PHYSIOLOGY
|
| Resource |
| Rats |
SHRSP/Izm(strainID=409) |
