論文 - 詳細
| RRC ID | 87186 |
|---|---|
| 著者 | Wang S, Cao S, Arhatte M, Li D, Shi Y, Kurz S, Hu J, Wang L, Shao J, Atzberger A, Wang Z, Wang C, Zang W, Fleming I, Wettschureck N, Honoré E, Offermanns S. |
| タイトル | Adipocyte Piezo1 mediates obesogenic adipogenesis through the FGF1/FGFR1 signaling pathway in mice. |
| ジャーナル | Nat Commun |
| Abstract |
White adipose tissue (WAT) expansion in obesity occurs through enlargement of preexisting adipocytes (hypertrophy) and through formation of new adipocytes (adipogenesis). Adipogenesis results in WAT hyperplasia, smaller adipocytes and a metabolically more favourable form of obesity. How obesogenic WAT hyperplasia is induced remains, however, poorly understood. Here, we show that the mechanosensitive cationic channel Piezo1 mediates diet-induced adipogenesis. Mice lacking Piezo1 in mature adipocytes demonstrated defective differentiation of preadipocyte into mature adipocytes when fed a high fat diet (HFD) resulting in larger adipocytes, increased WAT inflammation and reduced insulin sensitivity. Opening of Piezo1 in mature adipocytes causes the release of the adipogenic fibroblast growth factor 1 (FGF1), which induces adipocyte precursor differentiation through activation of the FGF-receptor-1. These data identify a central feed-back mechanism by which mature adipocytes control adipogenesis during the development of obesity and suggest Piezo1-mediated adipocyte mechano-signalling as a mechanism to modulate obesity and its metabolic consequences. |
| 巻・号 | 11(1) |
| ページ | 2303 |
| 公開日 | 2020-5-8 |
| DOI | 10.1038/s41467-020-16026-w |
| PII | 10.1038/s41467-020-16026-w |
| PMID | 32385276 |
| PMC | PMC7211025 |
| MeSH | Adipocytes / metabolism* Adipogenesis / physiology Adipose Tissue, White / metabolism Animals Calorimetry Cells, Cultured Female Fibroblast Growth Factor 1 / genetics Fibroblast Growth Factor 1 / metabolism* Flow Cytometry Humans Immunohistochemistry In Situ Nick-End Labeling Insulin / blood Interleukin-6 / blood Ion Channels / genetics Ion Channels / metabolism* Male Mice Receptor, Fibroblast Growth Factor, Type 1 / genetics Receptor, Fibroblast Growth Factor, Type 1 / metabolism* Signal Transduction / genetics Signal Transduction / physiology |
| IF | 12.121 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 15 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC09616 |