論文 - 詳細
| RRC ID | 87213 |
|---|---|
| 著者 | Ito Y, Nakahara F, Kagoya Y, Kurokawa M. |
| タイトル | CD62L expression level determines the cell fate of myeloid progenitors. |
| ジャーナル | Stem Cell Reports |
| Abstract |
Hematopoietic cells differentiate through several progenitors in a hierarchical manner, and recent single-cell analyses have revealed substantial heterogeneity within each progenitor. Although common myeloid progenitors (CMPs) are defined as a multipotent cell population that can differentiate into granulocyte-monocyte progenitors (GMPs) and megakaryocyte-erythrocyte progenitors (MEPs), and GMPs generate neutrophils and monocytes, these myeloid progenitors must contain some lineage-committed progenitors. Through gene expression analysis at single-cell levels, we identified CD62L as a marker to reveal the heterogeneity. We confirmed that CD62L-negative CMPs represent "bona fide" CMPs, whereas CD62L-high CMPs are mostly restricted to GMP potentials both in mice and humans. In addition, we identified CD62L-negative GMPs as the most immature subsets in GMPs and Ly6C+CD62L-intermediate and Ly6C+CD62L-high GMPs are skewed to neutrophil and monocyte differentiation in mice, respectively. Our findings contribute to more profound understanding about the mechanism of myeloid differentiation. |
| 巻・号 | 16(12) |
| ページ | 2871-2886 |
| 公開日 | 2021-12-14 |
| DOI | 10.1016/j.stemcr.2021.10.012 |
| PII | S2213-6711(21)00547-6 |
| PMID | 34798065 |
| PMC | PMC8693656 |
| MeSH | Animals Cell Differentiation Cell Lineage* Gene Expression Profiling Gene Expression Regulation Humans L-Selectin / metabolism* Megakaryocytes / cytology Megakaryocytes / metabolism Mice Mice, Inbred C57BL Monocytes / cytology Monocytes / metabolism Myeloid Progenitor Cells / cytology* Myeloid Progenitor Cells / metabolism* Neutrophils / cytology Neutrophils / metabolism |
| IF | 6.032 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC00267 |