論文 - 詳細
| RRC ID | 87306 |
|---|---|
| 著者 | Narukawa M, Takahashi S, Saito T, Saido TC, Misaka T. |
| タイトル | Analysis of Taste Sensitivities in App Knock-In Mouse Model of Alzheimer's Disease. |
| ジャーナル | J Alzheimers Dis |
| Abstract |
BACKGROUND:Some studies have reported a decline in taste sensitivities in patients with Alzheimer's disease. However, the detail remains unknown. OBJECTIVE:We investigated the effect of cognitive impairment on taste sensitivity using an App knock-in mouse model of Alzheimer's disease. METHODS:Behavioral assays, a brief access test, and a 48 h two-bottle preference test, to assess taste sensitivities were started from 12 months of age in mice that were confirmed to have impaired cognition. RESULTS:In the assays, there was no significant difference in taste sensitivities between wild type and App knock-in mice. Additionally, no apparent difference was observed in the expression of taste markers in their taste bud cells. CONCLUSION:We concluded that cognitive impairment might not greatly affect taste sensitivity. |
| 巻・号 | 76(3) |
| ページ | 997-1004 |
| 公開日 | 2020-1-1 |
| DOI | 10.3233/JAD-200284 |
| PII | JAD200284 |
| PMID | 32568206 |
| PMC | PMC7504995 |
| MeSH | Alzheimer Disease / genetics* Alzheimer Disease / metabolism* Amyloid beta-Peptides / genetics* Amyloid beta-Peptides / metabolism Amyloid beta-Protein Precursor / genetics* Animals Behavior, Animal Brain / metabolism* Disease Models, Animal Memory Disorders / genetics Memory Disorders / metabolism Mice, Transgenic Plaque, Amyloid / genetics Plaque, Amyloid / metabolism Taste |
| リソース情報 | |
| 実験動物マウス | RBRC06344 |