論文 - 詳細
| RRC ID | 87488 |
|---|---|
| 著者 | Ostenrath AM, Faturos N, Çiftci Çobanoğlu YI, Serneels B, Jeong I, Dongel Dayanc E, Enz A, Hinrichsen F, Mutlu AK, Bardenhewer R, Jetti SK, Neuhauss SCF, Jurisch-Yaksi N, Yaksi E. |
| タイトル | Inhibition mediated by group III metabotropic glutamate receptors regulates habenula activity and defensive behaviors. |
| ジャーナル | Nat Commun |
| Abstract |
Inhibition plays a key role in brain functions. While typically linked to GABA, inhibition can be induced by glutamate via metabotropic glutamate receptors (mGluRs). Here, we investigated the role of mGluR-mediated inhibition in the habenula, a conserved, glutamatergic brain hub involved in adaptive and defensive behaviors. We found that zebrafish and mice habenula express group III mGluRs. We showed that group III mGluRs regulate membrane potential and calcium activity of zebrafish habenula. Perturbing group III mGluRs increased sensory-evoked excitation and reduced selectivity. We identified inhibition as the primary communication mode among habenula neurons. Blocking group III mGluRs reduces this inhibition and increases neural synchrony. Consistently, we demonstrated that multisensory integration in the habenula relies on competitive suppression, that partly depends on group III mGluRs. Genetic and pharmacological perturbation of group III mGluRs amplified neural responses and defensive behaviors. Our findings highlight an essential role for mGluR-driven inhibition in encoding information and regulating defensive behaviors. |
| 巻・号 | 16(1) |
| ページ | 7187 |
| 公開日 | 2025-8-5 |
| DOI | 10.1038/s41467-025-62115-z |
| PII | 10.1038/s41467-025-62115-z |
| PMID | 40764295 |
| PMC | PMC12325729 |
| MeSH | Animals Behavior, Animal* / physiology Calcium / metabolism Female Habenula* / metabolism Habenula* / physiology Male Membrane Potentials / physiology Mice Mice, Inbred C57BL Neural Inhibition* / physiology Neurons / metabolism Neurons / physiology Receptors, Metabotropic Glutamate* / antagonists & inhibitors Receptors, Metabotropic Glutamate* / genetics Receptors, Metabotropic Glutamate* / metabolism Zebrafish Zebrafish Proteins / genetics Zebrafish Proteins / metabolism |
| IF | 12.121 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 28 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ゼブラフィッシュ | Tg(dao:GAL4VP16)rw0148a Tg(narp:GAL4VP16)rw0143a |