論文 - 詳細
| RRC ID | 87554 |
|---|---|
| 著者 | Arafa D, van de Korput J, Braaker PN, Higgins KP, Meijns NRC, Marshall-Phelps KLH, Meng J, Soong D, Scalia E, Lathem K, Keatinge M, Richmond C, Klingseisen A, Main M, Neely SA, Hampton DW, Duncan GJ, Schenk GJ, Groot ML, Chandran S, Emery B, Luchicchi A, Kole MHP, Williams AC, Lyons DA. |
| タイトル | Myelin sheaths in the central nervous system can withstand damage and dynamically remodel. |
| ジャーナル | Science |
| Abstract |
Myelin damage is a hallmark of several neurological disorders, but how it occurs remains to be fully understood. In this study, we found that early damage in zebrafish and rodent demyelination models is characterized by myelin swelling. We show, through live imaging, that myelin swelling does not always lead to myelin loss and that swellings can sometimes resolve, allowing sheaths to remodel. Increased neuronal activity during early demyelination exacerbates myelin damage, whereas reducing neuronal activity mitigates myelin swelling in both zebrafish and mice. In human multiple sclerosis tissue, myelin swelling is also dynamic and is prominent around active lesions. Our data indicate that myelin swelling is a conserved feature of demyelination and that damage to myelin sheaths can resolve, opening opportunities for targeting human disease. |
| 巻・号 | 391(6786) |
| ページ | eadr4661 |
| 公開日 | 2026-2-12 |
| DOI | 10.1126/science.adr4661 |
| PMID | 41678629 |
| PMC | PMC7618902 |
| MeSH | Animals Central Nervous System* / pathology Demyelinating Diseases* / pathology Demyelinating Diseases* / physiopathology Disease Models, Animal Female Humans Male Mice Mice, Inbred C57BL Multiple Sclerosis / pathology Multiple Sclerosis / physiopathology Myelin Sheath* / pathology Myelin Sheath* / physiology Myelin Sheath* / ultrastructure Neurons / physiology Zebrafish |
| IF | 41.846 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 112 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 99.6 |
| リソース情報 | |
| ゼブラフィッシュ | Tg(vglut2a:Gal4) hspGFF62A |