Reference - Detail
| RRC ID | 88019 |
|---|---|
| Author | Inomata R, Saito R, Wang D, Shimazaki S. |
| Title | Bacillus subtilis TO-A suppresses the age-related decline in locomotion in Caenorhabditis elegans. |
| Journal | Commun Biol |
| Abstract |
Research on the role of probiotics in maintaining locomotor function in aged Caenorhabditis elegans is limited. Therefore, we investigated whether a probiotic strain, Bacillus subtilis TO-A (BSTOA), which extends the lifespan of worms can prevent age-related declines in the locomotor functions of aged worms. This study revealed that aged worms fed BSTOA (BSTOA_day13) maintained better locomotor function than those fed Escherichia coli OP50 (OP50_day13). BSTOA_day13 exhibited better activity than OP50_day13 in maintaining actin structure during age-related changes in body wall muscles. Notably, the expression levels of oxidative stress-related genes fluctuated in BSTOA_day13; these worms also displayed high survival rates based on the paraquat assay. An examination of the locomotor function of aged gpx-7 mutants revealed that even worms fed BSTOA had a reduced thrashing rate. Therefore, consuming BSTOA may prevent the decline in age-related locomotor functions, such as symptoms of sarcopenia in humans, by inhibiting the decrease in gpx-7 expression in aged worms. |
| Volume | 8(1) |
| Pages | 1492 |
| Published | 2025-10-22 |
| DOI | 10.1038/s42003-025-08879-y |
| PII | 10.1038/s42003-025-08879-y |
| PMID | 41125718 |
| PMC | PMC12546617 |
| MeSH | Aging* / physiology Animals Bacillus subtilis* / physiology Caenorhabditis elegans* / genetics Caenorhabditis elegans* / microbiology Caenorhabditis elegans* / physiology Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Locomotion* / drug effects Longevity Oxidative Stress Probiotics* / pharmacology |
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 5 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm2166 |