論文 - 詳細
| RRC ID | 88041 |
|---|---|
| 著者 | Liu Y, Huang L, Wang R, Qi F, Liu Y, Chen Q, Mialon M, Chen L, Pinan-Lucarre B, Gao S. |
| タイトル | Nicotine induces abnormal motor coupling through sensitization of a mechanosensory circuit in Caenorhabditis elegans. |
| ジャーナル | PLoS Biol |
| Abstract |
Nicotine exposure elicits diverse behavioral changes, yet the underlying neural pathways and molecular mechanisms remain incompletely understood. Here, we demonstrate that chronic nicotine exposure markedly increases both the initiation and duration of reversals in Caenorhabditis elegans. Strikingly, these reversals were tightly coupled with the rhythmic body contractions of the defecation motor program (DMP). Through pharmacological, genetic, in situ electrophysiological, and calcium imaging analyses, we show that nicotine enhances the activity of the AVA interneuron via selective upregulation of ACR-16, a nicotinic ACh receptor critical for nicotine-induced motor coupling. Ablation of touch receptor neurons (TRNs) or inhibition of TRNs-mediated mechanosensation completely abolished this coupling. Furthermore, optogenetic activation of TRNs in nicotine-treated animals evoked stronger AVA depolarization, and nicotine amplified gentle touch-evoked reversals. Together, these findings reveal a potential interoceptive effect of nicotine mediated by sensitization of the TRNs-AVA mechanosensory pathway, providing new insight into the neural and molecular basis of nicotine's modulation of sensory-motor coupling. |
| 巻・号 | 23(10) |
| ページ | e3003423 |
| 公開日 | 2025-10-1 |
| DOI | 10.1371/journal.pbio.3003423 |
| PII | PBIOLOGY-D-25-01396 |
| PMID | 41042799 |
| PMC | PMC12507281 |
| MeSH | Animals Caenorhabditis elegans* / drug effects Caenorhabditis elegans* / physiology Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Defecation / drug effects Interneurons / drug effects Interneurons / metabolism Interneurons / physiology Mechanotransduction, Cellular* / drug effects Nicotine* / pharmacology Nicotinic Agonists / pharmacology Optogenetics Receptors, Nicotinic / metabolism Sensory Receptor Cells / drug effects |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 9 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm3342 tm863 tm2515 tm4472 tm3863 tm3172 tm3506 tm3785 tm7970 tm4085 |