Reference - Detail
| RRC ID | 88046 |
|---|---|
| Author | Zhang H, Meléndez A. |
| Title | Conserved components of the macroautophagy machinery in Caenorhabditis elegans. |
| Journal | Genetics |
| Abstract |
Macroautophagy involves the sequestration of cytoplasmic contents in a double-membrane autophagosome and its subsequent delivery to lysosomes for degradation and recycling. In Caenorhabditis elegans, autophagy participates in diverse processes such as stress resistance, cell fate specification, tissue remodeling, aging, and adaptive immunity. Genetic screens in C. elegans have identified a set of metazoan-specific autophagy genes that form the basis for our molecular understanding of steps unique to the autophagy pathway in multicellular organisms. Suppressor screens have uncovered multiple mechanisms that modulate autophagy activity under physiological conditions. C. elegans also provides a model to investigate how autophagy activity is coordinately controlled at an organismal level. In this chapter, we will discuss the molecular machinery, regulation, and physiological functions of autophagy, and also methods utilized for monitoring autophagy during C. elegans development. |
| Volume | 229(4) |
| Published | 2025-4-17 |
| DOI | 10.1093/genetics/iyaf007 |
| PII | 8105738 |
| PMID | 40180610 |
| PMC | PMC12005284 |
| MeSH | Animals Autophagosomes / metabolism Autophagy* / genetics Caenorhabditis elegans* / genetics Caenorhabditis elegans* / growth & development Caenorhabditis elegans* / metabolism Caenorhabditis elegans* / physiology Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Lysosomes / metabolism Macroautophagy* / genetics |
| Altmetric score |
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| The most frequently cited source | Bluesky |
| Total number of mentions | 11 |
| Altmetric score changes over past 6months | 0.2 |
| Resource | |
| C.elegans | tm3425 tm3948 |