論文 - 詳細
| RRC ID | 88063 |
|---|---|
| 著者 | Wu YC, Beets I, Fox BW, Fajardo Palomino D, Chen L, Liao CP, Vandewyer E, Lin LY, He CW, Chen LT, Lin CT, Schroeder FC, Pan CL. |
| タイトル | Intercellular sphingolipid signaling mediates aversive learning in C. elegans. |
| ジャーナル | Curr Biol |
| Abstract |
Physiological stress in non-neural tissues drives aversive learning for sensory cues associated with stress. However, the identities of signals derived from non-neural tissues and the mechanisms by which these signals mediate aversive learning remain elusive. Here, we show that intercellular sphingolipid signaling contributes to aversive learning under mitochondrial stress in C. elegans. We found that stress-induced aversive learning requires sphingosine kinase, SPHK-1, the enzyme that produces sphingosine-1-phosphate (S1P). Genetic and biochemical studies revealed an intercellular signaling pathway in which intestinal or hypodermal SPHK-1 signals through the neuronal G protein-coupled receptor, SPHR-1, and modulates responses of the octopaminergic RIC neuron to promote aversive learning. We further show that SPHK-1-mediated sphingolipid signaling is required for learned aversion of Chryseobacterium indologenes, a bacterial pathogen found in the natural habitats of C. elegans, which causes mitochondrial stress. Taken together, our work reveals a sphingolipid signaling pathway that communicates from intestinal or hypodermal tissues to neurons to promote aversive learning in response to mitochondrial stress and pathogen infection. |
| 巻・号 | 35(10) |
| ページ | 2323-2336.e9 |
| 公開日 | 2025-5-19 |
| DOI | 10.1016/j.cub.2025.03.082 |
| PII | S0960-9822(25)00429-4 |
| PMID | 40252647 |
| PMC | PMC12799178 |
| MeSH | Animals Avoidance Learning* / physiology Caenorhabditis elegans* / genetics Caenorhabditis elegans* / microbiology Caenorhabditis elegans* / physiology Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Lysophospholipids Mitochondria Phosphotransferases (Alcohol Group Acceptor) / genetics Phosphotransferases (Alcohol Group Acceptor) / metabolism Signal Transduction* Sphingolipids* / metabolism Sphingosine / analogs & derivatives Sphingosine / metabolism Sphingosine Kinase Stress, Physiological |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | Bluesky |
| 各媒体での言及数の合計 | 8 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm2146 tm4341 |