Reference - Detail
| RRC ID | 88120 |
|---|---|
| Author | Castiglioni VG, Villena-Giménez A, Herek D, González-Sánchez A, Toft C, Gómez GG, Elena SF. |
| Title | Latent infection of Caenorhabditis elegans by Orsay virus induces age-dependent immunity and cross-protection. |
| Journal | Nat Commun |
| Abstract |
The C. elegans-Orsay virus pathosystem provides a powerful model for investigating the mechanisms that govern viral infection and immunity. Here, we focus on two key aspects of this interaction: the impact of lifelong latent infections and the dynamics of superinfection. By tracking the course of a lifelong infection, we demonstrate that the infection remains latent, with animals maintaining control over viral replication for most of their lifespan. Furthermore, we show that animals previously exposed to the virus can suppress viral replication following a second inoculation, indicative of an acquired immune response. Primary infections led to changes in transcriptomic and small RNA profiles, which varied depending on the developmental stage of the host and the timing of analysis. In contrast, superinfection disrupted multiple sRNA classes. Over time, the ability to control repeated viral reactivations declined, whereas resistance to superinfection was stable, ultimately favoring the primary infecting virus. This phenomenon was dependent on a functional RNA interference pathway. |
| Volume | 16(1) |
| Pages | 7123 |
| Published | 2025-8-2 |
| DOI | 10.1038/s41467-025-62522-2 |
| PII | 10.1038/s41467-025-62522-2 |
| PMID | 40753171 |
| PMC | PMC12318037 |
| MeSH | Animals Caenorhabditis elegans* / genetics Caenorhabditis elegans* / immunology Caenorhabditis elegans* / virology Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Cross Protection* / immunology Host-Pathogen Interactions / genetics Host-Pathogen Interactions / immunology Nodaviridae* / immunology Nodaviridae* / physiology RNA Interference Superinfection / immunology Superinfection / virology Transcriptome Virus Latency* / immunology Virus Replication / immunology |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Bluesky |
| Total number of mentions | 9 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm894 tm936 tm1021 |