Reference - Detail
| RRC ID | 88131 |
|---|---|
| Author | Kim K, Telger A, Sarkar G, Surya S, Rothi MH, Meers MP, Wang SY, Greer EL. |
| Title | Transgenerational adaptation to hypoxia. |
| Journal | Sci Adv |
| Abstract |
Epigenetic inheritance alerts naïve descendants to prepare for stresses that could still be present, whereas distant descendants return to a basal state after several generations without stress. However, organisms are frequently exposed to stresses successively across generations. We found that parental hypoxia exposure increased P0 longevity, caused intergenerational lipid reduction, and elicited transgenerational fertility reduction that was dependent on generationally transmitted small RNAs. Here, we find that Caenorhabditis elegans adapt to repeated generational stresses. We show that, upon two repeated generational hypoxia exposures, the life-span extension is eliminated, and after four repeated generational hypoxia exposures, the reduced fertility is eliminated. Transgenerational adaptation also occurred in response to changes in glucose availability. Transgenerational hypoxia adaptation is dependent on the H3K27 trimethyltransferase PRC2 complex, and we identified transgenerationally adapted genes. Our findings reveal that transgenerational adaptation occurs and suggest that H3K27me3 is a critical modification for adapting to repeated generational stresses. |
| Volume | 11(43) |
| Pages | eadv9451 |
| Published | 2025-10-24 |
| DOI | 10.1126/sciadv.adv9451 |
| PMID | 41134902 |
| PMC | PMC12551719 |
| MeSH | Adaptation, Physiological* / genetics Animals Caenorhabditis elegans* / genetics Caenorhabditis elegans* / physiology Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism Epigenesis, Genetic Fertility / genetics Histones / metabolism Hypoxia* / genetics Hypoxia* / metabolism Longevity / genetics |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Bluesky |
| Total number of mentions | 17 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm1200 tm892 tm3121 tm4259 tm894 |