論文 - 詳細
| RRC ID | 88289 |
|---|---|
| 著者 | Choi JH, Jo HS, Lim S, Kim HT, Lee KW, Moon KH, Ha T, Kwak SS, Kim Y, Lee EJ, Joe CO, Kim JW. |
| タイトル | mTORC1 accelerates retinal development via the immunoproteasome. |
| ジャーナル | Nat Commun |
| Abstract |
The numbers and types of cells constituting vertebrate neural tissues are determined by cellular mechanisms that couple neurogenesis to the proliferation of neural progenitor cells. Here we identified a role of mammalian target of rapamycin complex 1 (mTORC1) in the development of neural tissue, showing that it accelerates progenitor cell cycle progression and neurogenesis in mTORC1-hyperactive tuberous sclerosis complex 1 (Tsc1)-deficient mouse retina. We also show that concomitant loss of immunoproteasome subunit Psmb9, which is induced by Stat1 (signal transducer and activator of transcription factor 1), decelerates cell cycle progression of Tsc1-deficient mouse retinal progenitor cells and normalizes retinal developmental schedule. Collectively, our results establish a developmental role for mTORC1, showing that it promotes neural development through activation of protein turnover via a mechanism involving the immunoproteasome. |
| 巻・号 | 9(1) |
| ページ | 2502 |
| 公開日 | 2018-6-27 |
| DOI | 10.1038/s41467-018-04774-9 |
| PII | 10.1038/s41467-018-04774-9 |
| PMID | 29950673 |
| PMC | PMC6021445 |
| MeSH | Animals Cell Cycle / physiology Cell Division / physiology Cysteine Endopeptidases / metabolism Embryo, Mammalian Female Mechanistic Target of Rapamycin Complex 1 / metabolism* Mice Mice, Knockout Neural Stem Cells / metabolism Neurogenesis / physiology* Proteasome Endopeptidase Complex / immunology Proteasome Endopeptidase Complex / metabolism Retina / cytology Retina / growth & development* Retina / metabolism STAT1 Transcription Factor / metabolism Signal Transduction / physiology Tuberous Sclerosis Complex 1 Protein / genetics Tuberous Sclerosis Complex 1 Protein / metabolism* |
| IF | 12.121 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC03952 |