Reference - Detail
| RRC ID | 88808 |
|---|---|
| Author | Chen Y, Qin Y, Fan T, Qiu C, Zhang Y, Dai M, Zhou Y, Sun Q, Guo Y, Hao Y, Jiang Y. |
| Title | Solobacterium moorei promotes tumor progression via the Integrin α2/β1-PI3K-AKT-mTOR-C-myc signaling pathway in colorectal cancer. |
| Journal | Int J Biol Sci |
| Abstract |
More and more evidences show that the imbalance of intestinal flora homeostasis can contribute to the progression of colorectal cancer (CRC). Solobacterium moorei (S. moorei), an anaerobic Gram-positive bacillus, was found to be enriched in fecal samples from CRC patients. However, the signaling regulatory mechanism of S. moorei promoting CRC progression remain unknown. Three CRC mouse models (ApcMin/+ mice, AOM/DSS-treated mice and subcutaneous colorectal xenograft mice) and two cell lines (DLD-1 and HT-29) were used to investigate the biological functions and molecular mechanisms of S. moorei on tumor progression of CRC in vivo and in vitro. S. moorei abundance increased in fecal samples and tumor tissues, and was significantly positively correlated with tumor staging of CRC. S. moorei promoted tumor progression in various CRC mouse models and it selectively adhered to cancer cells in comparison to colonic mucosal epithelial cells, enhancing CRC cell proliferation and inhibiting cell apoptosis. Mechanistically, S. moorei cellwall protein Cna B-type domain-containing protein binds to integrin α2/β1 on CRC cells, leading to the activation of PI3K-AKT-mTOR-C-myc pathway via phospho-FAK, thereby promoted tumor cell growth and progression. Blockade of integrin α2/β1 abolished S. moorei-mediated oncogenic response in vitro and in vivo. In summary, this study demonstrated that S. moorei promoted tumor progression via the integrin α2/β1-PI3K-AKT-mTOR-C-myc signaling pathway, which is a novel specific pathogen-mediated mechanism that might be a new potential target for CRC prevention, diagnosis, and treatment. |
| Volume | 21(4) |
| Pages | 1497-1512 |
| Published | 2025-1-1 |
| DOI | 10.7150/ijbs.102742 |
| PII | ijbsv21p1497 |
| PMID | 39990665 |
| PMC | PMC11844286 |
| MeSH | Animals Cell Line, Tumor Cell Proliferation Colorectal Neoplasms* / metabolism Colorectal Neoplasms* / microbiology Colorectal Neoplasms* / pathology Disease Progression Female HT29 Cells Humans Integrin alpha2 / metabolism Male Mice Phosphatidylinositol 3-Kinases / metabolism Proto-Oncogene Proteins c-akt / metabolism Proto-Oncogene Proteins c-myc / metabolism Signal Transduction / physiology TOR Serine-Threonine Kinases / metabolism |
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| The most frequently cited source | Wikipedia |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| General Microbes | JCM10645 |