| RRC ID |
959
|
| Author |
Moriuchi M, Moriuchi H, Mon HM, Kanbara H.
|
| Title |
Dichotomous effects of Plasmodium falciparum antigens on expression of human immunodeficiency virus (HIV) coreceptors and on infectability of CD4 cells by HIV.
|
| Journal |
J Infect Dis
|
| Abstract |
Many microbial coinfections accelerate the progression of human immunodeficiency virus (HIV) disease. Coinfections of Plasmodium falciparum malaria and HIV-1 are common; however, past studies of the effects of P. falciparum malaria on HIV-1 infection have shown little effect. The present study found that P. falciparum antigens (PF-Ags) variably regulate the expression of HIV-1 coreceptors and modulate the infectability of CD4 cells by HIV-1. Shortly after PF-Ag stimulation, CCR5 expression was down-regulated, but CXCR4 expression was modestly up-regulated. Subsequently, CCR5 expression on CD4 cells was induced. Infectability of PF-Ag-stimulated peripheral blood mononuclear cells (PBMC) by R5 HIV-1 was decreased, regardless of the duration of PF-Ag stimulation or CCR5 expression levels. In contrast, X4 HIV-1 replication was enhanced briefly in PBMC stimulated with PF-Ags but was inhibited with longer stimulation. Decreased HIV-1 infectability resulted, in part, from endogenous production of interferon-gamma. These results may explain why malaria previously did not appear to accelerate HIV-1 disease progression.
|
| Volume |
186(8)
|
| Pages |
1194-7
|
| Published |
2002-10-15
|
| DOI |
10.1086/343814
|
| PII |
JID020520
|
| PMID |
12355376
|
| MeSH |
Animals
Antigens, Protozoan / metabolism*
CD4-Positive T-Lymphocytes / metabolism*
CD4-Positive T-Lymphocytes / virology*
Down-Regulation
Enzyme-Linked Immunosorbent Assay
Flow Cytometry
Gene Expression Regulation*
HIV Infections / immunology
HIV-1 / growth & development
HIV-1 / metabolism*
Humans
Plasmodium falciparum / immunology
Plasmodium falciparum / physiology*
Receptors, CCR5 / analysis
Receptors, CCR5 / genetics
Receptors, CCR5 / metabolism
Receptors, CXCR4 / analysis
Receptors, CXCR4 / genetics
Receptors, CXCR4 / metabolism
Receptors, HIV / analysis
Receptors, HIV / genetics
Receptors, HIV / metabolism*
Time Factors
Up-Regulation
Virus Replication
|
| IF |
5.022
|
| Times Cited |
8
|
|
WOS Category
|
INFECTIOUS DISEASES
IMMUNOLOGY
MICROBIOLOGY
|
| Resource |
| Pathogenic microorganisms |
|
