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  • Search Condition : Filter (MeSH = Amyotrophic Lateral Sclerosis / metabolism)
Species Resource
Drosophila Ubiquilins regulate autophagic flux through mTOR signalling and lysosomal acidification.
C.elegans tm7084 The THO Complex Coordinates Transcripts for Synapse Development and Dopamine Neuron Survival.
Drosophila Self-assembly of FUS through its low-complexity domain contributes to neurodegeneration.
Drosophila RNA binding mediates neurotoxicity in the transgenic Drosophila model of TDP-43 proteinopathy.
DNA material GFP-OPTN-WT (RDB16707) , GFP-OPTN-E50K (RDB16708) , GFP-OPTN-E478G (RDB16709) Determination of cytoplasmic optineurin foci sizes using image correlation spectroscopy.
Human and Animal Cells 201B7(HPS0063) , HPS0251 , HPS0252 A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model.
C.elegans tm1 , tm4439 FUS Regulates Activity of MicroRNA-Mediated Gene Silencing.
C.elegans tm1411 , tm1441 The secreted MSP domain of C. elegans VAPB homolog VPR-1 patterns the adult striated muscle mitochondrial reticulum via SMN-1.
Zebrafish Tg(CM-isl1:GFP) Non-nuclear Pool of Splicing Factor SFPQ Regulates Axonal Transcripts Required for Normal Motor Development.
DNA material Genome Network Project Human cDNA IRAL001I24 (HGY080616) FUS interacts with nuclear matrix-associated protein SAFB1 as well as Matrin3 to regulate splicing and ligand-mediated transcription.
Drosophila 9553R-3 Familial Amyotrophic Lateral Sclerosis-linked Mutations in Profilin 1 Exacerbate TDP-43-induced Degeneration in the Retina of Drosophila melanogaster through an Increase in the Cytoplasmic Localization of TDP-43.
C.elegans tm4439 Caenorhabditis elegans RNA-processing protein TDP-1 regulates protein homeostasis and life span.
C.elegans tm4391 , tm4720 , tm4076 , tm4396 The tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43.
C.elegans tm1447 , tm1877 Inhibition of Cytohesins Protects against Genetic Models of Motor Neuron Disease.
Mice GFP-LC3#53(RBRC00806) Stress-Induced CDK5 Activation Disrupts Axonal Transport via Lis1/Ndel1/Dynein.
Drosophila Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration.
C.elegans tm1411 The amyotrophic lateral sclerosis 8 protein VAPB is cleaved, secreted, and acts as a ligand for Eph receptors.