生物種
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リソース名
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RRC ID
|
タイトル
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ジャーナル
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公開日
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外部リンク
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実験動物マウス
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RBRCGD000108
,
RBRCGD000110
|
72270
|
Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis.
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EMBO J |
2018-6-1 |
Pubmed
Full text
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ショウジョウバエ
|
4887R-3
,
4901R-3
,
4901R-4
,
5013R-2
,
5013R-3
,
6013R-2
,
7069R-1
,
7069R-2
,
7470R-2
,
7470R-3
,
...
|
68073
|
ZNF598 co-translationally titrates poly(GR) protein implicated in the pathogenesis of C9ORF72-associated ALS/FTD.
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Nucleic Acids Res |
2021-11-8 |
Pubmed
Full text
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ゼブラフィッシュ
|
|
64793
|
Multi-phaseted problems of TDP-43 in selective neuronal vulnerability in ALS.
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Cell Mol Life Sci |
2021-3-11 |
Pubmed
Full text
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ヒト・動物細胞
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CiRA00026(HPS0294)
|
63110
|
TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS.
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Cell |
2020-10-29 |
Pubmed
Full text
|
ゼブラフィッシュ
|
Tg(hb9:Venus)
|
60093
|
Aberrant axon branching via Fos-B dysregulation in FUS-ALS motor neurons.
|
EBioMedicine |
2019-7-1 |
Pubmed
Full text
|
ゼブラフィッシュ
|
Tg(HuC:GVP), UAS:GFP
|
59925
|
Myelin degeneration induced by mutant superoxide dismutase 1 accumulation promotes amyotrophic lateral sclerosis.
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Glia |
2019-10-1 |
Pubmed
Full text
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線虫
|
tm776
|
59317
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Single copy/knock-in models of ALS SOD1 in C. elegans suggest loss and gain of function have different contributions to cholinergic and glutamatergic neurodegeneration.
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PLoS Genet |
2018-10-1 |
Pubmed
Full text
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ショウジョウバエ
|
|
57169
|
Hippo, Drosophila MST, is a novel modifier of motor neuron degeneration induced by knockdown of Caz, Drosophila FUS.
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Exp Cell Res |
2018-10-15 |
Pubmed
Full text
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ショウジョウバエ
|
|
57126
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TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response.
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PLoS Genet |
2019-5-1 |
Pubmed
Full text
|
線虫
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tm776
|
56203
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A V-to-F substitution in SK2 channels causes Ca2+ hypersensitivity and improves locomotion in a C. elegans ALS model.
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Sci Rep |
2018-7-16 |
Pubmed
Full text
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線虫
|
tm7084
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56197
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The THO Complex Coordinates Transcripts for Synapse Development and Dopamine Neuron Survival.
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Cell |
2018-9-6 |
Pubmed
Full text
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ショウジョウバエ
|
|
54545
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Self-assembly of FUS through its low-complexity domain contributes to neurodegeneration.
|
Hum Mol Genet |
2018-4-15 |
Pubmed
Full text
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ショウジョウバエ
|
|
54543
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RNA binding mediates neurotoxicity in the transgenic Drosophila model of TDP-43 proteinopathy.
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Hum Mol Genet |
2013-11-15 |
Pubmed
Full text
|
線虫
|
tm1
,
tm4439
|
53958
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FUS Regulates Activity of MicroRNA-Mediated Gene Silencing.
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Mol Cell |
2018-3-1 |
Pubmed
Full text
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ゼブラフィッシュ
|
pT2KXIGdeltaIN
|
51568
|
Glycine-alanine dipeptide repeat protein contributes to toxicity in a zebrafish model of C9orf72 associated neurodegeneration.
|
Mol Neurodegener |
2017-1-14 |
Pubmed
Full text
|
ゼブラフィッシュ
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Tg(Huc:Kaede)
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49697
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ALS-linked protein disulfide isomerase variants cause motor dysfunction.
|
EMBO J |
2016-4-15 |
Pubmed
Full text
|
遺伝子材料
|
pEF-BOS FLAG-mouse Rab29 (RDB14971)
,
pEF-BOS FLAG-mouse Rab29-Q67L (RDB14972)
,
pEF-BOS FLAG-mouse Rab29-T21N (RDB14973).
|
48779
|
C9orf72 and RAB7L1 regulate vesicle trafficking in amyotrophic lateral sclerosis and frontotemporal dementia.
|
Brain |
2017-4-1 |
Pubmed
Full text
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ショウジョウバエ
|
9553R-3
|
46765
|
Familial Amyotrophic Lateral Sclerosis-linked Mutations in Profilin 1 Exacerbate TDP-43-induced Degeneration in the Retina of Drosophila melanogaster through an Increase in the Cytoplasmic Localization of TDP-43.
|
J Biol Chem |
2016-11-4 |
Pubmed
Full text
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線虫
|
tm1411
|
45983
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VAPB/ALS8 MSP ligands regulate striated muscle energy metabolism critical for adult survival in caenorhabditis elegans.
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PLoS Genet |
2013-1-1 |
Pubmed
Full text
|
ゼブラフィッシュ
|
Tg(isl1:GFP)/rw0
|
33660
|
Early interneuron dysfunction in ALS: insights from a mutant sod1 zebrafish model.
|
Ann Neurol |
2013-2-1 |
Pubmed
Full text
|