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  • Search Condition : Filter (MeSH = Imatinib Mesylate)
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Human and Animal Cells Sensitivity of SNX2-ABL1 toward tyrosine kinase inhibitors distinct from that of BCR-ABL1.
Human and Animal Cells Sorafenib induces apoptosis specifically in cells expressing BCR/ABL by inhibiting its kinase activity to activate the intrinsic mitochondrial pathway.
Human and Animal Cells A novel FRET-based biosensor for the measurement of BCR-ABL activity and its response to drugs in living cells.
Human and Animal Cells Enhancement of imatinib-induced apoptosis of BCR/ABL-expressing cells by nutlin-3 through synergistic activation of the mitochondrial apoptotic pathway.
Human and Animal Cells PECAM-1 is involved in BCR/ABL signaling and may downregulate imatinib-induced apoptosis of Philadelphia chromosome-positive leukemia cells.
Human and Animal Cells Inhibition of the PI3K/Akt/GSK3 pathway downstream of BCR/ABL, Jak2-V617F, or FLT3-ITD downregulates DNA damage-induced Chk1 activation as well as G2/M arrest and prominently enhances induction of apoptosis.
Human and Animal Cells TCS (RCB0638) Ca Ski (RCB1947) HB-EGF and PDGF mediate reciprocal interactions of carcinoma cells with cancer-associated fibroblasts to support progression of uterine cervical cancers.
Human and Animal Cells Mechanisms for the proliferation of eosinophilic leukemia cells by FIP1L1-PDGFRalpha.
Human and Animal Cells MEK inhibitor enhances the inhibitory effect of imatinib on pancreatic cancer cell growth.
Human and Animal Cells Successful treatment of a chronic-phase T-315I-mutated chronic myelogenous leukemia patient with a combination of imatinib and interferon-alfa.
Human and Animal Cells K562 Depsipeptide enhances imatinib mesylate-induced apoptosis of Bcr-Abl-positive cells and ectopic expression of cyclin D1, c-Myc or active MEK abrogates this effect.
Human and Animal Cells K562 Ectopic cyclin D1 expression blocks STI571-induced erythroid differentiation of K562 cells.
Human and Animal Cells K562 Inactivation of ERK accelerates erythroid differentiation of K562 cells induced by herbimycin A and STI571 while activation of MEK1 interferes with it.
Human and Animal Cells K562 A novel mechanism for imatinib mesylate-induced cell death of BCR-ABL-positive human leukemic cells: caspase-independent, necrosis-like programmed cell death mediated by serine protease activity.
Human and Animal Cells Imatinib induces demethylation of miR-203 gene: an epigenetic mechanism of anti-tumor effect of imatinib.