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  • Search Condition : Filter (MeSH = Imatinib Mesylate)
Species Resource Title
Human and Animal Cells Inhibition of the PI3K/Akt/GSK3 pathway downstream of BCR/ABL, Jak2-V617F, or FLT3-ITD downregulates DNA damage-induced Chk1 activation as well as G2/M arrest and prominently enhances induction of apoptosis.
Human and Animal Cells Imatinib induces demethylation of miR-203 gene: an epigenetic mechanism of anti-tumor effect of imatinib.
Human and Animal Cells PECAM-1 is involved in BCR/ABL signaling and may downregulate imatinib-induced apoptosis of Philadelphia chromosome-positive leukemia cells.
Human and Animal Cells Successful treatment of a chronic-phase T-315I-mutated chronic myelogenous leukemia patient with a combination of imatinib and interferon-alfa.
Human and Animal Cells MEK inhibitor enhances the inhibitory effect of imatinib on pancreatic cancer cell growth.
Human and Animal Cells Mechanisms for the proliferation of eosinophilic leukemia cells by FIP1L1-PDGFRalpha.
Human and Animal Cells Enhancement of imatinib-induced apoptosis of BCR/ABL-expressing cells by nutlin-3 through synergistic activation of the mitochondrial apoptotic pathway.
Human and Animal Cells A novel FRET-based biosensor for the measurement of BCR-ABL activity and its response to drugs in living cells.
Human and Animal Cells Sorafenib induces apoptosis specifically in cells expressing BCR/ABL by inhibiting its kinase activity to activate the intrinsic mitochondrial pathway.
Human and Animal Cells Sensitivity of SNX2-ABL1 toward tyrosine kinase inhibitors distinct from that of BCR-ABL1.
Human and Animal Cells TCS (RCB0638) Ca Ski (RCB1947) HB-EGF and PDGF mediate reciprocal interactions of carcinoma cells with cancer-associated fibroblasts to support progression of uterine cervical cancers.
Human and Animal Cells K562 A novel mechanism for imatinib mesylate-induced cell death of BCR-ABL-positive human leukemic cells: caspase-independent, necrosis-like programmed cell death mediated by serine protease activity.
Human and Animal Cells K562 Inactivation of ERK accelerates erythroid differentiation of K562 cells induced by herbimycin A and STI571 while activation of MEK1 interferes with it.
Human and Animal Cells K562 Ectopic cyclin D1 expression blocks STI571-induced erythroid differentiation of K562 cells.
Human and Animal Cells K562(RCB0027) Depsipeptide enhances imatinib mesylate-induced apoptosis of Bcr-Abl-positive cells and ectopic expression of cyclin D1, c-Myc or active MEK abrogates this effect.