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  • 29 Hits
  • Search Condition : Filter (MeSH = Mechanistic Target of Rapamycin Complex 1)
Species Resource Title
DNA material pMXs-IP-EGFP-hATG13 (RDB19625) Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy.
Human and Animal Cells PC-3(RCB2145) Asteltoxin inhibits extracellular vesicle production through AMPK/mTOR-mediated activation of lysosome function.
Human and Animal Cells ST2(RCB0224) Peptide drugs accelerate BMP-2-induced calvarial bone regeneration and stimulate osteoblast differentiation through mTORC1 signaling.
Human and Animal Cells ATDC5(RCB0565) mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation.
Human and Animal Cells Atg5^(+/+)MEF(RCB2710) , Atg5^(-/-)MEF(RCB2711) Translational control during endoplasmic reticulum stress beyond phosphorylation of the translation initiation factor eIF2α.
Human and Animal Cells GSU(RCB2278) , TGBC11TKB(RCB1148) , SH-10-TC(RCB1940) , GSS(RCB2277) , HGC-27(RCB0500) , KE-39(RCB1434) , KE-97(RCB1435) , H-111-TC(RCB1884) , GCIY(RCB0555) Reduced phosphorylation of ribosomal protein S6 is associated with sensitivity to MEK inhibition in gastric cancer cells.
C.elegans tm1944 An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer.
C.elegans tm1944 Mg2+ Extrusion from Intestinal Epithelia by CNNM Proteins Is Essential for Gonadogenesis via AMPK-TORC1 Signaling in Caenorhabditis elegans.
Human and Animal Cells MC3T3-E1(RCB1126) PDMP, a ceramide analogue, acts as an inhibitor of mTORC1 by inducing its translocation from lysosome to endoplasmic reticulum.
Human and Animal Cells Sq-1(RCB1905) , LK-2(RCB1970) , LC-1/sq(RCB0455) , EBC-1(RCB1965) , RERF-LC-AI(RCB0444) Inhibition of Glutaminolysis Inhibits Cell Growth via Down-regulating Mtorc1 Signaling in Lung Squamous Cell Carcinoma.
Human and Animal Cells ATDC5(RCB0565) mTORC1 Signaling Promotes Limb Bud Cell Growth and Chondrogenesis.
DNA material pMRX-puro-HA-mouse PAT4 (RDB15392). Rab12 regulates mTORC1 activity and autophagy through controlling the degradation of amino-acid transporter PAT4.
C.elegans tm1027 , tm504 A novel sphingolipid-TORC1 pathway critically promotes postembryonic development in Caenorhabditis elegans.
C.elegans tm1027 , tm504 , tm2182 , tm1996 A Lipid-TORC1 Pathway Promotes Neuronal Development and Foraging Behavior under Both Fed and Fasted Conditions in C. elegans.
Human and Animal Cells K562(RCB1897) , T24(RCB0431) Phenylalanine sensitive K562-D cells for the analysis of the biochemical impact of excess amino acid.
Human and Animal Cells Atg5^(+/+)MEF(RCB2710) , Atg5^(-/-)MEF(RCB2711) A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS.
Human and Animal Cells OCUB-F(RCB0882) mTORC1 inhibition is required for sensitivity to PI3K p110α inhibitors in PIK3CA-mutant breast cancer.
Human and Animal Cells PC-12(RCB0009) Inhibition of autophagy enhances sunitinib-induced cytotoxicity in rat pheochromocytoma PC12 cells.
Human and Animal Cells Blockade of adipocyte differentiation by cordycepin.
Human and Animal Cells Inhibition of MEK/ERK signaling induces apoptosis of acute myelogenous leukemia cells via inhibition of eukaryotic initiation factor 4E-binding protein 1 and down-regulation of Mcl-1.