論文 - 詳細
| RRC ID | 61139 |
|---|---|
| 著者 | Mitsuishi M, Miyashita K, Muraki A, Tamaki M, Tanaka K, Itoh H. |
| タイトル | Dietary protein decreases exercise endurance through rapamycin-sensitive suppression of muscle mitochondria. |
| ジャーナル | Am J Physiol Endocrinol Metab |
| Abstract |
Loss of physical performance is linked not only to decreased activity in daily life but also to increased onset of cardiovascular diseases and mortality. A high-protein diet is recommended for aged individuals in order to preserve muscle mass; however, the regulation of muscle mitochondria by dietary protein has not been clarified. We investigated the long-term effects of a high-protein diet on muscle properties, focusing especially on muscle mitochondria. Mice were fed a high-protein diet from the age of 8 wk and examined for mitochondrial properties and exercise endurance at the ages of 20 and 50 wk. Compared with normal chow, a high-protein diet significantly decreased the amount of muscle mitochondria, mitochondrial activity, and running distance at 50 wk, although it increased muscle mass and grip power. Inhibition of TORC1-dependent signal pathways by rapamycin from 8 wk suppressed the decline in mitochondria and exercise endurance observed when mice were fed the high-protein diet in association with preserved AMPK activity. Collectively, these findings suggest a role for dietary protein as a suppressor of muscle mitochondria and indicate that the age-associated decline in exercise endurance might be accelerated by excessive dietary protein through rapamycin-sensitive suppression of muscle mitochondria. |
| 巻・号 | 305(7) |
| ページ | E776-84 |
| 公開日 | 2013-10-1 |
| DOI | 10.1152/ajpendo.00145.2013 |
| PII | ajpendo.00145.2013 |
| PMID | 23880314 |
| MeSH | Animals Cell Line Dietary Proteins / metabolism* Energy Metabolism / drug effects Energy Metabolism / physiology Hand Strength / physiology Mechanistic Target of Rapamycin Complex 1 Mice Mice, Inbred C57BL Mitochondria, Muscle / drug effects Mitochondria, Muscle / metabolism* Multiprotein Complexes / metabolism Muscle, Skeletal / drug effects Muscle, Skeletal / metabolism* Physical Conditioning, Animal / physiology* Physical Endurance / drug effects Physical Endurance / physiology* Signal Transduction / drug effects Signal Transduction / physiology Sirolimus / pharmacology TOR Serine-Threonine Kinases / metabolism |
| IF | 3.469 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 28 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | C2C12(RCB0987) |