論文 - 詳細
| RRC ID | 64325 |
|---|---|
| 著者 | Wei Y, Lee NN, Pan L, Dhakshnamoorthy J, Sun LL, Zofall M, Wheeler D, Grewal SIS. |
| タイトル | TOR targets an RNA processing network to regulate facultative heterochromatin, developmental gene expression and cell proliferation. |
| ジャーナル | Nat Cell Biol |
| Abstract |
Cell proliferation and differentiation require signalling pathways that enforce appropriate and timely gene expression. We find that Tor2, the catalytic subunit of the TORC1 complex in fission yeast, targets a conserved nuclear RNA elimination network, particularly the serine and proline-rich protein Pir1, to control gene expression through RNA decay and facultative heterochromatin assembly. Phosphorylation by Tor2 protects Pir1 from degradation by the ubiquitin-proteasome system involving the polyubiquitin Ubi4 stress-response protein and the Cul4-Ddb1 E3 ligase. This pathway suppresses widespread and untimely gene expression and is critical for sustaining cell proliferation. Moreover, we find that the dynamic nature of Tor2-mediated control of RNA elimination machinery defines gene expression patterns that coordinate fundamental chromosomal events during gametogenesis, such as meiotic double-strand-break formation and chromosome segregation. These findings have important implications for understanding how the TOR signalling pathway reprogrammes gene expression patterns and contributes to diseases such as cancer. |
| 巻・号 | 23(3) |
| ページ | 243-256 |
| 公開日 | 2021-3-1 |
| DOI | 10.1038/s41556-021-00631-y |
| PII | 10.1038/s41556-021-00631-y |
| PMID | 33574613 |
| PMC | PMC9260697 |
| MeSH | Cell Proliferation* Chromatin Assembly and Disassembly* Gene Expression Regulation, Fungal* Heterochromatin / genetics Heterochromatin / metabolism* Mitosis Phosphatidylinositol 3-Kinases / genetics Phosphatidylinositol 3-Kinases / metabolism* Phosphorylation Proteasome Endopeptidase Complex / genetics Proteasome Endopeptidase Complex / metabolism Proteolysis RNA Processing, Post-Transcriptional* Schizosaccharomyces / enzymology* Schizosaccharomyces / genetics Schizosaccharomyces / growth & development Schizosaccharomyces pombe Proteins / genetics Schizosaccharomyces pombe Proteins / metabolism* Ubiquitination |
| IF | 20.042 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 80 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
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