| RRC ID |
64325
|
| 著者 |
Wei Y, Lee NN, Pan L, Dhakshnamoorthy J, Sun LL, Zofall M, Wheeler D, Grewal SIS.
|
| タイトル |
TOR targets an RNA processing network to regulate facultative heterochromatin, developmental gene expression and cell proliferation.
|
| ジャーナル |
Nat Cell Biol
|
| Abstract |
Cell proliferation and differentiation require signalling pathways that enforce appropriate and timely gene expression. We find that Tor2, the catalytic subunit of the TORC1 complex in fission yeast, targets a conserved nuclear RNA elimination network, particularly the serine and proline-rich protein Pir1, to control gene expression through RNA decay and facultative heterochromatin assembly. Phosphorylation by Tor2 protects Pir1 from degradation by the ubiquitin-proteasome system involving the polyubiquitin Ubi4 stress-response protein and the Cul4-Ddb1 E3 ligase. This pathway suppresses widespread and untimely gene expression and is critical for sustaining cell proliferation. Moreover, we find that the dynamic nature of Tor2-mediated control of RNA elimination machinery defines gene expression patterns that coordinate fundamental chromosomal events during gametogenesis, such as meiotic double-strand-break formation and chromosome segregation. These findings have important implications for understanding how the TOR signalling pathway reprogrammes gene expression patterns and contributes to diseases such as cancer.
|
| 巻・号 |
23(3)
|
| ページ |
243-256
|
| 公開日 |
2021-3-1
|
| DOI |
10.1038/s41556-021-00631-y
|
| PII |
10.1038/s41556-021-00631-y
|
| PMID |
33574613
|
| PMC |
PMC9260697
|
| MeSH |
Cell Proliferation*
Chromatin Assembly and Disassembly*
Gene Expression Regulation, Fungal*
Heterochromatin / genetics
Heterochromatin / metabolism*
Mitosis
Phosphatidylinositol 3-Kinases / genetics
Phosphatidylinositol 3-Kinases / metabolism*
Phosphorylation
Proteasome Endopeptidase Complex / genetics
Proteasome Endopeptidase Complex / metabolism
Proteolysis
RNA Processing, Post-Transcriptional*
Schizosaccharomyces / enzymology*
Schizosaccharomyces / genetics
Schizosaccharomyces / growth & development
Schizosaccharomyces pombe Proteins / genetics
Schizosaccharomyces pombe Proteins / metabolism*
Ubiquitination
|
| IF |
20.042
|
| リソース情報 |
| 酵母 |
|
