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  • Search Condition : Filter (MeSH = Protein Kinase Inhibitors / chemistry)
Species Resource Title
Human and Animal Cells PC-9(RCB4455) Design, synthesis and evaluation of the osimertinib analogue (C-005) as potent EGFR inhibitor against NSCLC.
Human and Animal Cells Ba/F3(RCB4476) Lamellarin 14, a derivative of marine alkaloids, inhibits the T790M/C797S mutant epidermal growth factor receptor.
Human and Animal Cells RERF-LC-AI(RCB0444) A unique hinge binder of extremely selective aminopyridine-based Mps1 (TTK) kinase inhibitors with cellular activity.
Human and Animal Cells HuH-7 First Selective Small Molecule Inhibitor of FGFR4 for the Treatment of Hepatocellular Carcinomas with an Activated FGFR4 Signaling Pathway.
Human and Animal Cells Lu99(RCB1900) Discovery of imidazo[1,2-b]pyridazine derivatives: selective and orally available Mps1 (TTK) kinase inhibitors exhibiting remarkable antiproliferative activity.
Human and Animal Cells Ba/F3(RCB0805) , WEHI-3(RCB0035) EGFR Exon 18 Mutations in Lung Cancer: Molecular Predictors of Augmented Sensitivity to Afatinib or Neratinib as Compared with First- or Third-Generation TKIs.
Human and Animal Cells HuCCT1(RCB1960) , RBE(RCB1292) , SSP-25(RCB1293) , HuH-28(RCB1943) TAS-120 Overcomes Resistance to ATP-Competitive FGFR Inhibitors in Patients with FGFR2 Fusion-Positive Intrahepatic Cholangiocarcinoma.
Human and Animal Cells Ba/F3 Characterization of EGFR T790M, L792F, and C797S Mutations as Mechanisms of Acquired Resistance to Afatinib in Lung Cancer.
Human and Animal Cells 293T(RCB2202) Anti-tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC-dependent vulnerability.
Human and Animal Cells Li-7(RCB1941) ASP5878, a Novel Inhibitor of FGFR1, 2, 3, and 4, Inhibits the Growth of FGF19-Expressing Hepatocellular Carcinoma.
Human and Animal Cells PC-9(RCB4455) Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants.
Human and Animal Cells Ba/F3(RCB0805) , LC-2/ad(RCB0440) Alectinib shows potent antitumor activity against RET-rearranged non-small cell lung cancer.
Arabidopsis / Cultured plant cells, genes rpc00008 Identification of novel compounds that inhibit SnRK2 kinase activity by high-throughput screening.
Human and Animal Cells PC-3(RCB2145) PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptor, directly inhibits p38 MAPK.
Human and Animal Cells MKN45(RCB1001) In Vitro and In Vivo Activity of AMG 337, a Potent and Selective MET Kinase Inhibitor, in MET-Dependent Cancer Models.
Human and Animal Cells MCF7(RCB1904) , A549(RCB0098) Design, synthesis and biological evaluation of a new series of thiazolyl-pyrazolines as dual EGFR and HER2 inhibitors.
Human and Animal Cells A549(RCB0098) , MCF7(RCB1904) Design, Synthesis and Biological Evaluation of Pentacyclic Triterpene Derivatives: Optimization of Anti-ABL Kinase Activity.
Human and Animal Cells OCUB-M(RCB0881) Development of a potent and orally active activator of adenosine monophosphate-activated protein kinase (AMPK), ASP4132, as a clinical candidate for the treatment of human cancer.
Human and Animal Cells Ba/F3(RCB0805) Efficacy of irreversible EGFR-TKIs for the uncommon secondary resistant EGFR mutations L747S, D761Y, and T854A.
Human and Animal Cells CW-2(RCB0778) Overcoming resistance to HER2 inhibitors through state-specific kinase binding.