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Species Resource Title
Human and Animal Cells , Mice MC3T3-E1(RCB1126) , RBRC05524 Phosphorylation-dependent osterix degradation negatively regulates osteoblast differentiation.
Human and Animal Cells 293T(RCB2202) , Jurkat(RCB0806) Cell-type specific, inducible and acute degradation of targeted protein in mice by two degron systems.
DNA material pCMV-VSV-G-RSV-Rev (RDB04393) , pCAG-HIVgp (RDB04394) An IMiD-induced SALL4 degron system for selective degradation of target proteins.
DNA material pCAG-HIVgp (RDB04394) , pCMV-VSV-G-RSV-Rev (RDB04393) CRL2KLHDC3 and CRL1Fbxw7 cooperatively mediate c-Myc degradation.
Drosophila pVHL-mediated SMAD3 degradation suppresses TGF-β signaling.
DNA material pAID1.2-CMV-NmScarlet-mAID (RDB19226) , pAID1.2-EF1a-NmScarlet-mAID (RDB19227) , pAIDFA-CMV-NmScarlet-mAID (RDB19228) , pAIDFA-EF1a-NmScarlet-mAID (RDB19229) , pAID1.2-CMV-linearizing in pX330 (RDB19230) , pAID-EF1a- linearizing in pX330 (RDB19231) A super-sensitive auxin-inducible degron system with an engineered auxin-TIR1 pair.
Human and Animal Cells RAW 264(RCB0535) Gasdermin D mediates the maturation and release of IL-1α downstream of inflammasomes.
Yeast FY31941 Regulation of inorganic polyphosphate is required for proper vacuolar proteolysis in fission yeast.
Human and Animal Cells Atg5^(+/+)MEF(RCB2710) , Atg5^(-/-)MEF(RCB2711) Impaired proteolysis underlies autophagic dysfunction in Niemann-Pick type C disease.
Human and Animal Cells Atg5^(+/+)MEF(RCB2710) , Atg5^(-/-)MEF(RCB2711) Tau phosphorylation affects its axonal transport and degradation.
DNA material , Human and Animal Cells pCMV-VSV-G (RDB04392) , pCMV-VSV-G-RSV-Rev (RDB04393) , pCAG-HIVgp (RDB04394) , HCT116(RCB2979) Caspase cleavage releases a nuclear protein fragment that stimulates phospholipid scrambling at the plasma membrane.
Drosophila An N-terminal di-proline motif is essential for fatty acid-dependent degradation of Δ9-desaturase in Drosophila.
Human and Animal Cells MG6(RCB2403) Nucleus distribution of cathepsin B in senescent microglia promotes brain aging through degradation of sirtuins.
C.elegans tm1969 , tm2027 The G2-to-M Transition Is Ensured by a Dual Mechanism that Protects Cyclin B from Degradation by Cdc20-Activated APC/C.
Prokaryotes E. coli Keio collection Degp degrades a wide range of substrate proteins in Escherichia coli under stress conditions.
Human and Animal Cells T98G(RCB1954) High cell density increases glioblastoma cell viability under glucose deprivation via degradation of the cystine/glutamate transporter xCT (SLC7A11).
Human and Animal Cells ATDC5(RCB0565) Secreted tyrosine kinase Vlk negatively regulates Hedgehog signaling by inducing lysosomal degradation of Smoothened.
Human and Animal Cells Atg5^(+/+)MEF(RCB2710) , Atg5^(-/-)MEF(RCB2711) The N-Degron Pathway Mediates ER-phagy.
Drosophila Dysfunction of different cellular degradation pathways contributes to specific β-amyloid42-induced pathologies.
DNA material pMRX-bsr-ss-EGFP-FM4 (RDB17364) , pMRX-bsr-ss-EGFP-FM4-TMD (RDB17365) Differing susceptibility to autophagic degradation of two LC3-binding proteins: SQSTM1/p62 and TBC1D25/OATL1.