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  • Search Condition : Filter (MeSH = Pyrimidines / pharmacology)
Species Resource Title
Human and Animal Cells HeLa(RCB0007) , Hep G2(RCB1648) Adenosine deaminase inhibitor EHNA exhibits a potent anticancer effect against malignant pleural mesothelioma.
Human and Animal Cells HGC-27(RCB0500) A novel carbazole topoisomerase II poison, ER-37328: potent tumoricidal activity against human solid tumors in vitro and in vivo.
Human and Animal Cells K-562(RCB1635) Continuous Cytostatic Effects of BCR-ABL Tyrosine Kinase Inhibitors (TKIs) after Washout in Human Leukemic K562 Cells.
Human and Animal Cells PC-9(RCB4455) Effect of platinum‑based chemotherapy on the expression of natural killer group 2 member D ligands, programmed cell death‑1 ligand 1 and HLA class I in non‑small cell lung cancer.
Human and Animal Cells 253G1(HPS0002) Chemically defined conditions for long-term maintenance of pancreatic progenitors derived from human induced pluripotent stem cells.
Human and Animal Cells MCF7(RCB1904), L929 GANT61 and curcumin-loaded PLGA nanoparticles for GLI1 and PI3K/Akt-mediated inhibition in breast adenocarcinoma.
Mice B6;129-Siglec1(RBRC04395) Breast cancer cells promote CD169+ macrophage-associated immunosuppression through JAK2-mediated PD-L1 upregulation on macrophages.
Human and Animal Cells K562 Pharmacological inhibition of JAK3 enhances the antitumor activity of imatinib in human chronic myeloid leukemia.
Human and Animal Cells HuCCT1(RCB1960) , TFK-1(RCB2537) Therapeutic Targeting of the DNA Damage Response Using an ATR Inhibitor in Biliary Tract Cancer.
Human and Animal Cells HuCCT1(RCB1960) Dysregulated Expression of MITF in Subsets of Hepatocellular Carcinoma and Cholangiocarcinoma.
Human and Animal Cells MH7A(RCB1512) Kinase inhibitors of the IGF-1R as a potential therapeutic agent for rheumatoid arthritis.
Human and Animal Cells JHUEM-2(RCB1551) PI3K Inhibitors Synergize with FGFR Inhibitors to Enhance Antitumor Responses in FGFR2mutant Endometrial Cancers.
Mice B6.FVB-Tg(Col1a1-cre)1Kry(RBRC05603) Dullard deficiency causes hemorrhage in the adult ovarian follicles.
DNA material CSII-CMV-MCS-IRES2-Bsd (RDB04385) The CUL3-SPOP-DAXX axis is a novel regulator of VEGFR2 expression in vascular endothelial cells.
Human and Animal Cells The phosphoinositide-3-kinase (PI3K)-delta and gamma inhibitor, IPI-145 (Duvelisib), overcomes signals from the PI3K/AKT/S6 pathway and promotes apoptosis in CLL.
Human and Animal Cells Cbl negatively regulates erythropoietin-induced growth and survival signaling through the proteasomal degradation of Src kinase.
Human and Animal Cells Inhibition of the PI3K/Akt/GSK3 pathway downstream of BCR/ABL, Jak2-V617F, or FLT3-ITD downregulates DNA damage-induced Chk1 activation as well as G2/M arrest and prominently enhances induction of apoptosis.
Human and Animal Cells HDM2 regulation by AURKA promotes cell survival in gastric cancer.
Human and Animal Cells Inhibition of Rac1 promotes BMP-2-induced osteoblastic differentiation.
Human and Animal Cells Paracrine receptor activation by microenvironment triggers bypass survival signals and ALK inhibitor resistance in EML4-ALK lung cancer cells.