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  • Search Condition : Filter (MeSH = Sirolimus / pharmacology)
Species Resource
Mice GFP-LC3#53 Vitamin K3 attenuates cerulein-induced acute pancreatitis through inhibition of the autophagic pathway.
Yeast Dclp1 The reverse, but coordinated, roles of Tor2 (TORC1) and Tor1 (TORC2) kinases for growth, cell cycle and separase-mediated mitosis in Schizosaccharomyces pombe.
Yeast genome library (pTN-L1) L972 L975 JY741 JY746 Fission yeast TOR signaling is essential for the down-regulation of a hyperactivated stress-response MAP kinase under salt stress.
Pathogenic microorganisms The Aspergillus fumigatus SchASCH9 kinase modulates SakAHOG1 MAP kinase activity and it is essential for virulence.
C.elegans The C-Box Region of MAF1 Regulates Transcriptional Activity and Protein Stability.
C.elegans The genetics of isoflurane-induced developmental neurotoxicity.
Mice GFP-LC3#53(RBRC00806) Compromised autophagy precedes meniscus degeneration and cartilage damage in mice.
C.elegans tm3229 A stress-responsive system for mitochondrial protein degradation.
DNA material CSII-EF-RfA (RDB04387) , pCMV-VSV-G-RSV-Rev (RDB04393) , pCAG-HIVgp (RDB04394). Activation of mTOR by human T-cell leukemia virus type 1 Tax is important for the transformation of mouse T cells to interleukin-2-independent growth.
Yeast NA Nuclear localization domains of GATA activator Gln3 are required for transcription of target genes through dephosphorylation in Saccharomyces cerevisiae.
Mice GFP-LC3#53(RBRC00806) Autophagy upregulation promotes survival and attenuates doxorubicin-induced cardiotoxicity.
Mice GFP-LC3#53(RBRC00806) Prenatal alcohol exposure impairs autophagy in neonatal brain cortical microvessels.
Human and Animal Cells ATDC5(RCB0565) mTORC1 Signaling Promotes Limb Bud Cell Growth and Chondrogenesis.
Human and Animal Cells Transport-metabolism interplay: LXRalpha-mediated induction of human ABC transporter ABCC2 (cMOAT/MRP2) in HepG2 cells.
Human and Animal Cells Leucine restriction inhibits chondrocyte proliferation and differentiation through mechanisms both dependent and independent of mTOR signaling.
Human and Animal Cells Inhibition of MEK/ERK signaling induces apoptosis of acute myelogenous leukemia cells via inhibition of eukaryotic initiation factor 4E-binding protein 1 and down-regulation of Mcl-1.
Human and Animal Cells Novel HSP90 inhibitor NVP-AUY922 enhances the anti-tumor effect of temsirolimus against oral squamous cell carcinoma.
Human and Animal Cells mTORC1 inhibition is required for sensitivity to PI3K p110α inhibitors in PIK3CA-mutant breast cancer.
Human and Animal Cells Diversity of amino acid signaling pathways on autophagy regulation: a novel pathway for arginine.
Human and Animal Cells Antitumor activity and induction of TP53-dependent apoptosis toward ovarian clear cell adenocarcinoma by the dual PI3K/mTOR inhibitor DS-7423.