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  • Search Condition : Filter (MeSH = Sirolimus / pharmacology)
Species Resource
DNA material CSII-EF-RfA (RDB04387) , pCMV-VSV-G-RSV-Rev (RDB04393) , pCAG-HIVgp (RDB04394). Activation of mTOR by human T-cell leukemia virus type 1 Tax is important for the transformation of mouse T cells to interleukin-2-independent growth.
Yeast NA Nuclear localization domains of GATA activator Gln3 are required for transcription of target genes through dephosphorylation in Saccharomyces cerevisiae.
Human and Animal Cells mTORC1 inhibition is required for sensitivity to PI3K p110α inhibitors in PIK3CA-mutant breast cancer.
Human and Animal Cells Diversity of amino acid signaling pathways on autophagy regulation: a novel pathway for arginine.
Human and Animal Cells Antitumor activity and induction of TP53-dependent apoptosis toward ovarian clear cell adenocarcinoma by the dual PI3K/mTOR inhibitor DS-7423.
Human and Animal Cells Inhibition of the mTOR/S6K signal is necessary to enhance fluorouracil-induced apoptosis in gastric cancer cells with HER2 amplification.
Human and Animal Cells Novel HSP90 inhibitor NVP-AUY922 enhances the anti-tumor effect of temsirolimus against oral squamous cell carcinoma.
Human and Animal Cells FK506 enhanced osteoblastic differentiation in mesenchymal cells.
Human and Animal Cells FK506 induces chondrogenic differentiation of clonal mouse embryonic carcinoma cells, ATDC5.
Human and Animal Cells ST2 (RCB0224) RAW 264 (RCB0535) Antitumor effect of temsirolimus against oral squamous cell carcinoma associated with bone destruction.
Yeast Dclp1 The reverse, but coordinated, roles of Tor2 (TORC1) and Tor1 (TORC2) kinases for growth, cell cycle and separase-mediated mitosis in Schizosaccharomyces pombe.
Human and Animal Cells A172 (RCB2530) Dual blocking of mTor and PI3K elicits a prodifferentiation effect on glioblastoma stem-like cells.
Human and Animal Cells ST2 (RCB0224) Down-regulation of mTOR leads to up-regulation of osteoprotegerin in bone marrow cells.
Yeast genome library (pTN-L1) L972 L975 JY741 JY746 Fission yeast TOR signaling is essential for the down-regulation of a hyperactivated stress-response MAP kinase under salt stress.
Mice GFP-LC3#53 Vitamin K3 attenuates cerulein-induced acute pancreatitis through inhibition of the autophagic pathway.
Human and Animal Cells THP-1 (RCB1189) Involvement of mTOR in globular adiponectin-induced generation of reactive oxygen species.
Human and Animal Cells Inhibition of MEK/ERK signaling induces apoptosis of acute myelogenous leukemia cells via inhibition of eukaryotic initiation factor 4E-binding protein 1 and down-regulation of Mcl-1.
Human and Animal Cells Transport-metabolism interplay: LXRalpha-mediated induction of human ABC transporter ABCC2 (cMOAT/MRP2) in HepG2 cells.
Human and Animal Cells Leucine restriction inhibits chondrocyte proliferation and differentiation through mechanisms both dependent and independent of mTOR signaling.
Human and Animal Cells Negative regulation of melanogenesis by phospholipase D1 through mTOR/p70 S6 kinase 1 signaling in mouse B16 melanoma cells.