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  • Search Condition : Filter (MeSH = Sirolimus / pharmacology)
Species Resource Title
Drosophila DGRC#104863 A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing.
Human and Animal Cells HuH-7(RCB1366) Transient mTOR inhibition facilitates continuous growth of liver tumors by modulating the maintenance of CD133+ cell populations.
Human and Animal Cells HuH-7 mTOR inhibitors synergize on regression, reversal of gene expression, and autophagy in hepatocellular carcinoma.
Human and Animal Cells RAW 264(RCB0535) , THP-1(RCB1189) GADD34 inhibits activation-induced apoptosis of macrophages through enhancement of autophagy.
Human and Animal Cells 409B2(HPS0076) Imbalanced autophagy causes synaptic deficits in a human model for neurodevelopmental disorders.
Zebrafish Tg(isl1:GFP)rw0 Exosc2 deficiency leads to developmental disorders by causing a nucleotide pool imbalance in zebrafish.
Mice RBRC02231 RIPK1 Promotes Energy Sensing by the mTORC1 Pathway.
Human and Animal Cells TE-8(RCB2098) , TE-9(RCB1988) , TE-15(RCB1951) Chemokine (C-C Motif) Ligand 1 Derived from Tumor-Associated Macrophages Contributes to Esophageal Squamous Cell Carcinoma Progression via CCR8-Mediated Akt/Proline-Rich Akt Substrate of 40 kDa/Mammalian Target of Rapamycin Pathway.
Human and Animal Cells TGBC2TKB(RCB1130) Histone Deacetylase Inhibitors Inhibit the Proliferation of Gallbladder Carcinoma Cells by Suppressing AKT/mTOR Signaling.
C.elegans tm1340 Food-Dependent Plasticity in Caenorhabditis elegans Stress-Induced Sleep Is Mediated by TOR-FOXA and TGF-β Signaling.
C.elegans tm776 , tm1146 The genetics of isoflurane-induced developmental neurotoxicity.
C.elegans tm6082 The C-Box Region of MAF1 Regulates Transcriptional Activity and Protein Stability.
Pathogenic microorganisms The Aspergillus fumigatus SchASCH9 kinase modulates SakAHOG1 MAP kinase activity and it is essential for virulence.
Human and Animal Cells ATDC5(RCB0565) mTORC1 Signaling Promotes Limb Bud Cell Growth and Chondrogenesis.
C.elegans tm5447 Novel animal model defines genetic contributions for neuron-to-neuron transfer of α-synuclein.
Mice RBRC00806 Compromised autophagy precedes meniscus degeneration and cartilage damage in mice.
Mice RBRC00806 Prenatal alcohol exposure impairs autophagy in neonatal brain cortical microvessels.
C.elegans tm3229 A stress-responsive system for mitochondrial protein degradation.
Human and Animal Cells JHOC-7(RCB1688) , JHOC-9(RCB2226) , HTOA(RCB0692) , JHOS-2(RCB1521) , JHOS-3(RCB1546) , JHOS-4(RCB1678) Antitumor activity and induction of TP53-dependent apoptosis toward ovarian clear cell adenocarcinoma by the dual PI3K/mTOR inhibitor DS-7423.
Human and Animal Cells Hep G2 Diversity of amino acid signaling pathways on autophagy regulation: a novel pathway for arginine.