RRC ID 55879
Author Goetting DL, Soto R, Van Buskirk C.
Title Food-Dependent Plasticity in Caenorhabditis elegans Stress-Induced Sleep Is Mediated by TOR-FOXA and TGF-β Signaling.
Journal Genetics
Abstract Behavioral plasticity allows for context-dependent prioritization of competing drives, such as sleep and foraging. Despite the identification of neuropeptides and hormones implicated in dual control of sleep drive and appetite, our understanding of the mechanism underlying the conserved sleep-suppressing effect of food deprivation is limited. Caenorhabditis elegans provides an intriguing model for the dissection of sleep function and regulation as these nematodes engage a quiescence program following exposure to noxious conditions, a phenomenon known as stress-induced sleep (SIS). Here we show that food deprivation potently suppresses SIS, an effect enhanced at high population density. We present evidence that food deprivation reduces the need to sleep, protecting against the lethality associated with defective SIS. Additionally, we find that SIS is regulated by both target of rapamycin and transforming growth factor-β nutrient signaling pathways, thus identifying mechanisms coordinating sleep drive with internal and external indicators of food availability.
Volume 209(4)
Pages 1183-1195
Published 2018-8-1
DOI 10.1534/genetics.118.301204
PII genetics.118.301204
PMID 29925566
PMC PMC6063238
MeSH Animals Caenorhabditis elegans / physiology* Caenorhabditis elegans Proteins / metabolism* Drosophila Proteins / metabolism* Food Deprivation Gene Expression Regulation Models, Animal Signal Transduction* Sirolimus / pharmacology Sleep* Stress, Physiological TOR Serine-Threonine Kinases / metabolism* Trans-Activators / metabolism* Transforming Growth Factor beta / metabolism
IF 3.564
Times Cited 11
C.elegans tm1340