論文 - 詳細
| RRC ID | 80874 |
|---|---|
| 著者 | Godthi A, Min S, Das S, Cruz-Corchado J, Deonarine A, Misel-Wuchter K, Issuree PD, Prahlad V. |
| タイトル | Neuronal IL-17 controls Caenorhabditis elegans developmental diapause through CEP-1/p53. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
During metazoan development, how cell division and metabolic programs are coordinated with nutrient availability remains unclear. Here, we show that nutrient availability signaled by the neuronal cytokine, ILC-17.1, switches Caenorhabditis elegans development between reproductive growth and dormancy by controlling the activity of the tumor suppressor p53 ortholog, CEP-1. Specifically, upon food availability, ILC-17.1 signaling by amphid neurons promotes glucose utilization and suppresses CEP-1/p53 to allow growth. In the absence of ILC-17.1, CEP-1/p53 is activated, up-regulates cell-cycle inhibitors, decreases phosphofructokinase and cytochrome C expression, and causes larvae to arrest as stress-resistant, quiescent dauers. We propose a model whereby ILC-17.1 signaling links nutrient availability and energy metabolism to cell cycle progression through CEP-1/p53. These studies describe ancestral functions of IL-17 s and the p53 family of proteins and are relevant to our understanding of neuroimmune mechanisms in cancer. They also reveal a DNA damage-independent function of CEP-1/p53 in invertebrate development and support the existence of a previously undescribed C. elegans dauer pathway. |
| 巻・号 | 121(12) |
| ページ | e2315248121 |
| 公開日 | 2024-3-19 |
| DOI | 10.1073/pnas.2315248121 |
| PMID | 38483995 |
| PMC | PMC10963014 |
| MeSH | Animals Caenorhabditis elegans* / metabolism Caenorhabditis elegans Proteins* / metabolism DNA Damage Interleukin-17 / metabolism Tumor Suppressor Protein p53 / genetics Tumor Suppressor Protein p53 / metabolism |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm5218 tm5124 tm51240 |