論文 - 詳細
| RRC ID | 51858 |
|---|---|
| 著者 | Burdeos GC, Ito J, Eitsuka T, Nakagawa K, Kimura F, Miyazawa T. |
| タイトル | δ and γ tocotrienols suppress human hepatocellular carcinoma cell proliferation via regulation of Ras-Raf-MEK-ERK pathway-associated upstream signaling. |
| ジャーナル | Food Funct |
| Abstract |
Tocotrienol (T3) has recently gained increasing interest due to its anti-cancer effect. Here, we investigated the modulating effect of δ and γ T3 on the Ras-Raf-MEK-ERK oncogenic upstream signaling pathway in human hepatocellular carcinoma HepG2 cells. The results indicated that T3 regulated the upstream signaling cascades of this pathway. |
| 巻・号 | 7(10) |
| ページ | 4170-4174 |
| 公開日 | 2016-10-12 |
| DOI | 10.1039/c6fo00826g |
| PMID | 27713963 |
| MeSH | Carcinoma, Hepatocellular / metabolism Cell Proliferation / drug effects* Chromans / chemistry Chromans / pharmacology* Extracellular Signal-Regulated MAP Kinases / genetics Extracellular Signal-Regulated MAP Kinases / metabolism Gene Expression Regulation, Enzymologic / drug effects Gene Expression Regulation, Neoplastic / drug effects* Hep G2 Cells Humans Liver Neoplasms / metabolism MAP Kinase Kinase Kinases / genetics MAP Kinase Kinase Kinases / metabolism Signal Transduction / drug effects Vitamin E / analogs & derivatives* Vitamin E / chemistry Vitamin E / pharmacology raf Kinases / genetics raf Kinases / metabolism* ras Proteins / genetics ras Proteins / metabolism* |
| IF | 4.171 |
| 引用数 | 6 |
| リソース情報 | |
| ヒト・動物細胞 | Hep G2(RCB1886) |