論文 - 詳細
| RRC ID | 6257 |
|---|---|
| 著者 | Rieger S, Volkmann K, Köster RW. |
| タイトル | Polysialyltransferase expression is linked to neuronal migration in the developing and adult zebrafish. |
| ジャーナル | Dev Dyn |
| Abstract |
Modulation of cell-cell adhesion is crucial for regulating neuronal migration and maintenance of structural plasticity in the embryonic and mature brain. Such modulation can be obtained by the enzymatic attachment of polysialic acid (PSA) to the neural cell adhesion molecule (NCAM) by means of the polysialyltransferases STX and PST. Thus, differential expression of STX and PST is likely to be responsible for varying functions of PSA-NCAM during neuronal differentiation, maintenance, plasticity, and regeneration. We have isolated the zebrafish homologues of STX (St8sia2) and PST (St8sia4) and demonstrate that their expression in the embryonic and adult nervous system is often confined to regions of neuronal migration. Moreover, in the adult cerebellum, the complementary expression pattern of both polysialyltransferases suggests a function in regulating cerebellar neuronal plasticity. Enzymatic removal of PSA in the embryonic cerebellum results in impaired neuronal migration, suggesting that PSA-NCAM is a key regulator of motility for cerebellar neuronal progenitors. |
| 巻・号 | 237(1) |
| ページ | 276-85 |
| 公開日 | 2008-1-1 |
| DOI | 10.1002/dvdy.21410 |
| PMID | 18095350 |
| MeSH | Animals Brain / embryology Brain / growth & development Brain / metabolism Cell Adhesion / genetics Cell Adhesion / physiology Cell Movement / genetics* Cell Movement / physiology Central Nervous System / embryology Central Nervous System / growth & development Central Nervous System / metabolism Cerebellum / embryology Cerebellum / growth & development Cerebellum / metabolism Gene Expression Regulation, Developmental Immunohistochemistry Neural Cell Adhesion Molecules / genetics Neural Cell Adhesion Molecules / metabolism Neural Cell Adhesion Molecules / physiology Neurons / cytology Neurons / enzymology Neurons / metabolism* Reverse Transcriptase Polymerase Chain Reaction Sialic Acids / metabolism Sialyltransferases / genetics* Sialyltransferases / metabolism Zebrafish / embryology Zebrafish / genetics* Zebrafish / growth & development Zebrafish Proteins / genetics* Zebrafish Proteins / metabolism Zebrafish Proteins / physiology |
| IF | 3.275 |
| 引用数 | 20 |
| WOS 分野 | ANATOMY & MORPHOLOGY DEVELOPMENTAL BIOLOGY |
| リソース情報 | |
| ゼブラフィッシュ | rw0 (Tg(CM-isl1:GFP)) |