論文 - 詳細
RRC ID | 34923 |
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著者 | Ishiguro K, Kim J, Fujiyama-Nakamura S, Kato S, Watanabe Y. |
タイトル | A new meiosis-specific cohesin complex implicated in the cohesin code for homologous pairing. |
ジャーナル | EMBO Rep |
Abstract |
We identify a new mammalian cohesin subunit, RAD21-like protein (RAD21L), with sequence similarity to RAD21 and REC8. RAD21L localizes along axial elements in early meiotic prophase, in a manner that is spatiotemporally different to either REC8 or RAD21. Remarkably, RAD21L and REC8 have symmetrical, mutually exclusive localization on the not-yet-synapsed homologues, implying that the cohesin patterning could provide a code for homologue recognition. RAD21 transiently localizes to axial elements after the dissociation of RAD21L and REC8 in late pachytene, a period of recombination repair. Further, we show that the removal of cohesins and synaptonemal complex during late meiotic prophase is promoted by Polo-like kinase 1, which is similar to the mitotic prophase pathway. |
巻・号 | 12(3) |
ページ | 267-75 |
公開日 | 2011-3-1 |
DOI | 10.1038/embor.2011.2 |
PII | embor20112 |
PMID | 21274006 |
PMC | PMC3059921 |
MeSH | Amino Acid Sequence Animals Cell Cycle Proteins / chemistry Cell Cycle Proteins / genetics Cell Cycle Proteins / metabolism* Centromere Chromatography, Liquid Chromosomal Proteins, Non-Histone / chemistry Chromosomal Proteins, Non-Histone / genetics Chromosomal Proteins, Non-Histone / metabolism* Chromosome Pairing* Chromosome Segregation Chromosomes, Mammalian / metabolism* DNA-Binding Proteins Mass Spectrometry Meiosis* Mice Molecular Sequence Data Nuclear Proteins / metabolism Phosphoproteins / metabolism Prophase Protein Serine-Threonine Kinases / metabolism Protein Subunits Proto-Oncogene Proteins / metabolism Synaptonemal Complex / metabolism |
IF | 7.497 |
引用数 | 112 |
WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
リソース情報 | |
遺伝子材料 | pCRII-mRAD21L (RDB12167) |