Reference - Detail
| RRC ID | 10740 |
|---|---|
| Author | Tian C, Sen D, Shi H, Foehr ML, Plavskin Y, Vatamaniuk OK, Liu J. |
| Title | The RGM protein DRAG-1 positively regulates a BMP-like signaling pathway in Caenorhabditis elegans. |
| Journal | Development |
| Abstract |
The bone morphogenetic protein (BMP) signaling pathway regulates multiple developmental and homeostatic processes. Mutations in the pathway can cause a variety of somatic and hereditary disorders in humans. Multiple levels of regulation, including extracellular regulation, ensure proper spatiotemporal control of BMP signaling in the right cellular context. We have identified a modulator of the BMP-like Sma/Mab pathway in C. elegans called DRAG-1. DRAG-1 is the sole member of the repulsive guidance molecule (RGM) family of proteins in C. elegans, and is crucial in regulating body size and mesoderm development. Using a combination of molecular genetic and biochemical analyses, we demonstrate that DRAG-1 is a membrane-associated protein that functions at the ligand-receptor level to modulate the Sma/Mab pathway in a cell-type-specific manner. We further show that DRAG-1 positively modulates this BMP-like pathway by using a novel Sma/Mab-responsive reporter. Our work provides a direct link between RGM proteins and BMP signaling in vivo and a simple and genetically tractable system for mechanistic studies of RGM protein regulation of BMP pathways. |
| Volume | 137(14) |
| Pages | 2375-84 |
| Published | 2010-7-1 |
| DOI | 10.1242/dev.051615 |
| PII | dev.051615 |
| PMID | 20534671 |
| PMC | PMC2889605 |
| MeSH | Animals Bone Morphogenetic Proteins / genetics Bone Morphogenetic Proteins / metabolism Bone Morphogenetic Proteins / physiology* Caenorhabditis elegans* / genetics Caenorhabditis elegans* / growth & development Caenorhabditis elegans* / metabolism Humans Membrane Proteins / genetics Membrane Proteins / metabolism* Mutation Neurons / metabolism Protein Binding / genetics Proteins / genetics Proteins / metabolism Signal Transduction / genetics* |
| IF | 5.611 |
| Times Cited | 21 |
| WOS Category | DEVELOPMENTAL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| Total number of mentions | 0 |
| Resource | |
| C.elegans | tm3773 |