| RRC ID |
11008
|
| 著者 |
Nishimura K, Nakagawa T, Ono K, Ogita H, Sakamoto T, Yamamoto N, Okita K, Yamanaka S, Ito J.
|
| タイトル |
Transplantation of mouse induced pluripotent stem cells into the cochlea.
|
| ジャーナル |
Neuroreport
|
| Abstract |
This study examined the potential of induced pluripotent stem (iPS) cells for use as a source of transplants for the restoration of auditory spiral ganglion neurons. We monitored neurite outgrowth from iPS cell-derived neural progenitors toward cochlear hair cells ex vivo, and followed their survival and fates after transplantation into mouse cochleae in vivo. Neurons derived from iPS cells projected neurites toward cochlear hair cells. The settlement of iPS cell-derived neurons was observed 1 week after transplantation into the cochlea. Some transplants expressed vesicular glutamate transporter 1, which is a marker for glutamatergic neurons. These findings indicate that iPS cells can be used as a source of transplants for the regeneration of spiral ganglion neurons.
|
| 巻・号 |
20(14)
|
| ページ |
1250-4
|
| 公開日 |
2009-9-23
|
| DOI |
10.1097/WNR.0b013e32832ff287
|
| PMID |
19625987
|
| MeSH |
Animals
Animals, Newborn
Cell Line
Cell Survival
Cells, Cultured
Cochlea / surgery*
Coculture Techniques
Embryonic Stem Cells / physiology
Fibroblasts
Hair Cells, Auditory / physiology
Mice
Mice, Inbred ICR
Neurites / physiology
Neurogenesis
Neurons / physiology*
Pluripotent Stem Cells / physiology*
Pluripotent Stem Cells / transplantation*
Spiral Ganglion / cytology*
Time Factors
Vesicular Glutamate Transport Protein 1 / metabolism
|
| IF |
1.394
|
| 引用数 |
62
|
|
WOS 分野
|
NEUROSCIENCES
|
| リソース情報 |
| ヒト・動物細胞 |
MC3T3-G2/PA6(RCB1127) |
