論文 - 詳細
| RRC ID | 11123 |
|---|---|
| 著者 | Chen W, Hing H. |
| タイトル | The L1-CAM, Neuroglian, functions in glial cells for Drosophila antennal lobe development. |
| ジャーナル | Dev Neurobiol |
| Abstract |
Although considerable progress has been made in understanding the roles of olfactory receptor neurons (ORNs) and projection neurons (PNs) in Drosophila antennal lobe (AL) development, the roles of glia have remained largely mysterious. Here, we show that during Drosophila metamorphosis, a population of midline glial cells in the brain undergoes extensive cellular remodeling and is closely associated with the collateral branches of ORN axons. These glial cells are required for ORN axons to project across the midline and establish the contralateral wiring in the ALs. We find that Neuroglian (Nrg), the Drosophila homolog of the vertebrate cell adhesion molecule, L1, is expressed and functions in the midline glial cells to regulate their proper development. Loss of Nrg causes the disruption in glial morphology and the agenesis of the antennal commissural tract. Our genetic analysis further demonstrates that the functions of Nrg in the midline glia require its ankyrin-binding motif. We propose that Nrg is an important regulator of glial morphogenesis and axon guidance in AL development. |
| 巻・号 | 68(8) |
| ページ | 1029-45 |
| 公開日 | 2008-7-1 |
| DOI | 10.1002/dneu.20644 |
| PMID | 18446783 |
| MeSH | Animals Axons / metabolism Brain / growth & development* Brain / metabolism Cell Adhesion Molecules, Neuronal / metabolism Cell Adhesion Molecules, Neuronal / physiology Cell Differentiation / physiology Cell Surface Extensions / metabolism Cell Surface Extensions / physiology Drosophila / growth & development* Drosophila / metabolism Drosophila Proteins / metabolism Drosophila Proteins / physiology Immunohistochemistry Neural Cell Adhesion Molecule L1 / metabolism Neural Cell Adhesion Molecule L1 / physiology* Neuroglia / cytology Neuroglia / metabolism Neuroglia / physiology* Neurons / cytology Neurons / metabolism Neurons / physiology Olfactory Nerve / metabolism Olfactory Nerve / physiology Olfactory Receptor Neurons / cytology Olfactory Receptor Neurons / metabolism Olfactory Receptor Neurons / physiology |
| IF | 3.935 |
| 引用数 | 15 |
| WOS 分野 | NEUROSCIENCES DEVELOPMENTAL BIOLOGY |
| リソース情報 | |
| ショウジョウバエ | Nrg(CG1634) |