RRC ID 11296
Author Iwano M, Hill ES, Mori A, Mishima T, Mishima T, Ito K, Kanzaki R.
Title Neurons associated with the flip-flop activity in the lateral accessory lobe and ventral protocerebrum of the silkworm moth brain.
Journal J. Comp. Neurol.
Abstract The lateral accessory lobe (LAL) and the ventral protocerebrum (VPC) are a pair of symmetrical neural structures in the insect brain. The LAL-VPC is regarded as the major target of olfactory responding neurons as well as the control center for olfactory-evoked sequential zigzag turns. Previous studies of the silkworm moth Bombyx mori showed that these turns are controlled by long-lasting anti-phasic activities of the flip-flopping descending neurons with dendrites in the LAL-VPC. To elucidate the neural mechanisms underlying the generation of this alternating activity between the LAL-VPC units of both hemispheres, we first analyzed the detailed neural architecture of the LAL-VPC and identified five subregions. We then investigated the morphology and physiological responses of the LAL-VPC neurons by intracellular recording and staining and morphologically identified three types of bilateral neurons and three types of unilateral neurons. Bilateral neurons showed either brief or cyclic long-lasting responses. At least some neurons of the latter type produced gamma-aminobutyric acid (GABA). Unilateral neurons linking the LAL and VPC, in contrast, showed long-lasting or quick alternating activity. Timing analysis of the activity onset of each neural type suggests that quick reciprocal neural transmission between unilateral neurons would be responsible for the generation of long-lasting activity in one LAL-VPC unit, which lasts for up to a few seconds. Reciprocal inhibition and excitation by the bilateral neurons with long-lasting activities would mediate the alternating long-lasting activity between both LAL-VPC units, which might last for up to 20 seconds.
Volume 518(3)
Pages 366-88
Published 2010-2-1
DOI 10.1002/cne.22224
PMID 19950256
MeSH Action Potentials / physiology Animals Behavior, Animal / physiology Bombyx / cytology* Bombyx / physiology Brain / cytology* Brain / physiology Coloring Agents Dendrites / physiology Dendrites / ultrastructure Electrophysiology Excitatory Postsynaptic Potentials / physiology Flight, Animal / physiology Functional Laterality / physiology Image Cytometry Inhibitory Postsynaptic Potentials / physiology Locomotion / physiology Male Neural Inhibition / physiology Neural Pathways / cytology* Neural Pathways / physiology Neurons / cytology* Neurons / physiology Reaction Time / physiology Smell / physiology* Staining and Labeling Synaptic Transmission / physiology Time Factors gamma-Aminobutyric Acid / metabolism
IF 3.239
Times Cited 26
Silkworms ?