論文 - 詳細
| RRC ID | 11549 |
|---|---|
| 著者 | Kimura K, Ote M, Tazawa T, Yamamoto D. |
| タイトル | Fruitless specifies sexually dimorphic neural circuitry in the Drosophila brain. |
| ジャーナル | Nature |
| Abstract |
The Drosophila fruitless (fru) gene product Fru has been postulated to be a neural sex determination factor that directs development of the central nervous system (CNS), thereby producing male-typical courtship behaviour and inducing male-specific muscle. Male-specific Fru protein is expressed in small groups of neurons scattered throughout the CNS of male, but not female, Drosophila. Collectively, these observations suggest that Fru 'masculinizes' certain neurons, thereby establishing neural substrates for male-typical behaviour. However, specific differences between neurons resulting from the presence or absence of Fru are unknown. Previous studies have suggested that Fru might result in sexual differences in the CNS at the functional level, as no overt sexual dimorphism in CNS structure was discernible. Here we identify a subset of fru-expressing interneurons in the brain that show marked sexual dimorphism in their number and projection pattern. We also demonstrate that Fru supports the development of neurons with male-specific dendritic fields, which are programmed to die during female development as a result of the absence of Fru. Thus, Fru expression can produce a male-specific neural circuit, probably used during heterosexual courtship, by preventing cell death in identifiable neurons. |
| 巻・号 | 438(7065) |
| ページ | 229-33 |
| 公開日 | 2005-11-10 |
| DOI | 10.1038/nature04229 |
| PII | nature04229 |
| PMID | 16281036 |
| MeSH | Animals Apoptosis Brain / cytology* Brain / physiology* Courtship Dendrites / physiology Drosophila Proteins / deficiency Drosophila Proteins / genetics Drosophila Proteins / metabolism* Drosophila melanogaster / classification Drosophila melanogaster / cytology Drosophila melanogaster / genetics Drosophila melanogaster / physiology* Female Interneurons / cytology Interneurons / metabolism Male Nerve Tissue Proteins / deficiency Nerve Tissue Proteins / genetics Nerve Tissue Proteins / metabolism* Neural Pathways / physiology* Sex Characteristics* Sexual Behavior, Animal / physiology Transcription Factors / deficiency Transcription Factors / genetics Transcription Factors / metabolism* |
| IF | 42.779 |
| 引用数 | 181 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | |