論文 - 詳細
| RRC ID | 11580 |
|---|---|
| 著者 | Umetsu D, Murakami S, Sato M, Tabata T. |
| タイトル | The highly ordered assembly of retinal axons and their synaptic partners is regulated by Hedgehog/Single-minded in the Drosophila visual system. |
| ジャーナル | Development |
| Abstract |
During development of the Drosophila visual center, photoreceptor cells extend their axons (R axons) to the lamina ganglion layer, and trigger proliferation and differentiation of synaptic partners (lamina neurons) by delivering the inductive signal Hedgehog (Hh). This inductive mechanism helps to establish an orderly arrangement of connections between the R axons and lamina neurons, termed a retinotopic map because it results in positioning the lamina neurons in close vicinity to the corresponding R axons. We found that the bHLH-PAS transcription factor Single-minded (Sim) is induced by Hh in the lamina neurons and is required for the association of lamina neurons with R axons. In sim mutant brains, lamina neurons undergo the first step of differentiation but fail to associate with R axons. As a result, lamina neurons are set aside from R axons. The data reveal a novel mechanism for regulation of the interaction between axons and neuronal cell bodies that establishes precise neuronal networks. |
| 巻・号 | 133(5) |
| ページ | 791-800 |
| 公開日 | 2006-3-1 |
| DOI | 10.1242/dev.02253 |
| PII | dev.02253 |
| PMID | 16439478 |
| MeSH | Animals Axons / metabolism Axons / physiology* Basic Helix-Loop-Helix Transcription Factors / genetics Basic Helix-Loop-Helix Transcription Factors / physiology* Drosophila / cytology Drosophila / growth & development* Drosophila / metabolism Drosophila Proteins / genetics Drosophila Proteins / metabolism* ErbB Receptors / genetics ErbB Receptors / metabolism Hedgehog Proteins Larva / cytology Larva / growth & development Larva / metabolism Mutation Nuclear Proteins / genetics Nuclear Proteins / metabolism Nuclear Proteins / physiology* Photoreceptor Cells, Invertebrate / cytology Photoreceptor Cells, Invertebrate / growth & development* Photoreceptor Cells, Invertebrate / metabolism Protein Kinases / genetics Protein Kinases / metabolism Receptors, Invertebrate Peptide / genetics Receptors, Invertebrate Peptide / metabolism Retinal Ganglion Cells / cytology* Retinal Ganglion Cells / metabolism Synapses / metabolism Synapses / physiology |
| IF | 5.611 |
| 引用数 | 28 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| リソース情報 | |
| ショウジョウバエ | DGRC#105125 |