論文 - 詳細
| RRC ID | 11589 |
|---|---|
| 著者 | Fushima K, Tsujimura H. |
| タイトル | Precise control of fasciclin II expression is required for adult mushroom body development in Drosophila. |
| ジャーナル | Dev Growth Differ |
| Abstract |
Fasciclin II (FASII) is a cell adhesion molecule that participates in axonal pathfinding, fasciculation and divergence in the Drosophila nervous system. Here, we examined spatio-temporal control of fasII expression during the development of adult mushroom body (MB) and found that suppression of fasII in alpha'/beta' neurons is essential for the formation of adult alpha'/beta' and alpha/beta lobes. Of gamma, alpha'/beta' and alpha/beta neurons, which are derived sequentially from the same four MB neuroblasts, only gamma and alpha/beta neurons expressed fasII. When fasII was misexpressed in developing MB neurons, defects resulted, including loss or misdirection of adult alpha'/beta' lobes and concurrent misdirection of alpha/beta lobes. Although no gross anatomical defects were apparent in the larval MB lobes, alpha'/beta' lobes collapsed at the pupal stage when the larval lobe of gamma neurons degenerated. In addition, alpha/beta lobes, which developed at this time, were misdirected in close relationship with the collapse of alpha'/beta' lobes. These defects did not occur when fasII was overexpressed in only gamma and alpha/beta neurons, indicating that ectopic expression of fasII in alpha'/beta' neurons is required for the defects. Our findings also suggest that the alpha'/beta' lobe play a role in guiding the pathfinding by alpha/beta axons. |
| 巻・号 | 49(3) |
| ページ | 215-27 |
| 公開日 | 2007-4-1 |
| DOI | 10.1111/j.1440-169X.2007.00922.x |
| PII | DGD922 |
| PMID | 17394600 |
| MeSH | Animals Cell Adhesion Molecules, Neuronal / analysis Cell Adhesion Molecules, Neuronal / genetics Cell Adhesion Molecules, Neuronal / metabolism* Drosophila / embryology* Drosophila / genetics Mushroom Bodies / embryology* Mushroom Bodies / metabolism Mutation Nervous System / cytology Nervous System / embryology* Nervous System / metabolism Neurons / chemistry Neurons / metabolism Phenotype |
| IF | 1.723 |
| 引用数 | 24 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#112771 |