RRC ID 11589
著者 Fushima K, Tsujimura H.
タイトル Precise control of fasciclin II expression is required for adult mushroom body development in Drosophila.
ジャーナル Dev Growth Differ
Abstract Fasciclin II (FASII) is a cell adhesion molecule that participates in axonal pathfinding, fasciculation and divergence in the Drosophila nervous system. Here, we examined spatio-temporal control of fasII expression during the development of adult mushroom body (MB) and found that suppression of fasII in alpha'/beta' neurons is essential for the formation of adult alpha'/beta' and alpha/beta lobes. Of gamma, alpha'/beta' and alpha/beta neurons, which are derived sequentially from the same four MB neuroblasts, only gamma and alpha/beta neurons expressed fasII. When fasII was misexpressed in developing MB neurons, defects resulted, including loss or misdirection of adult alpha'/beta' lobes and concurrent misdirection of alpha/beta lobes. Although no gross anatomical defects were apparent in the larval MB lobes, alpha'/beta' lobes collapsed at the pupal stage when the larval lobe of gamma neurons degenerated. In addition, alpha/beta lobes, which developed at this time, were misdirected in close relationship with the collapse of alpha'/beta' lobes. These defects did not occur when fasII was overexpressed in only gamma and alpha/beta neurons, indicating that ectopic expression of fasII in alpha'/beta' neurons is required for the defects. Our findings also suggest that the alpha'/beta' lobe play a role in guiding the pathfinding by alpha/beta axons.
巻・号 49(3)
ページ 215-27
公開日 2007-4-1
DOI 10.1111/j.1440-169X.2007.00922.x
PII DGD922
PMID 17394600
MeSH Animals Cell Adhesion Molecules, Neuronal / analysis Cell Adhesion Molecules, Neuronal / genetics Cell Adhesion Molecules, Neuronal / metabolism* Drosophila / embryology* Drosophila / genetics Mushroom Bodies / embryology* Mushroom Bodies / metabolism Mutation Nervous System / cytology Nervous System / embryology* Nervous System / metabolism Neurons / chemistry Neurons / metabolism Phenotype
IF 1.723
引用数 24
WOS 分野 DEVELOPMENTAL BIOLOGY CELL BIOLOGY
リソース情報
ショウジョウバエ DGRC#112771