RRC ID 11594
Author Koana T, Okada MO, Ogura K, Tsujimura H, Sakai K.
Title Reduction of background mutations by low-dose X irradiation of Drosophila spermatocytes at a low dose rate.
Journal Radiat. Res.
Abstract A sex-linked recessive lethal mutation assay was performed in Drosophila melanogaster using immature spermatocytes and spermatogonia irradiated with X rays at a high or low dose rate. The mutation frequency in the sperm irradiated with a low dose at a low dose rate was significantly lower than that in the sham-irradiated group, whereas irradiation with a high dose resulted in a significant increase in the mutation frequency. It was obvious that the dose-response relationship was not linear, but rather was U-shaped. When mutant germ cells defective in DNA excision repair were used instead of wild-type cells, low-dose irradiation at a low dose rate did not reduce the mutation frequency. These observations suggest that error-free DNA repair functions were activated by low dose of low-dose-rate radiation and that this repaired spontaneous DNA damage rather than the X-ray-induced damage, thus producing a practical threshold.
Volume 167(2)
Pages 217-21
Published 2007-2
PMID 17390729
MeSH Animals Chromosome Mapping Crosses, Genetic DNA Damage DNA Repair Dose-Response Relationship, Radiation Drosophila / genetics* Drosophila / radiation effects* Female Genes, Recessive Male Mutation* Spermatocytes / radiation effects* Spermatozoa / radiation effects* X-Rays*
IF 2.53
Times Cited 20
WOS Category RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING BIOLOGY BIOPHYSICS
Resource
Drosophila