| RRC ID |
11594
|
| Author |
Koana T, Okada MO, Ogura K, Tsujimura H, Sakai K.
|
| Title |
Reduction of background mutations by low-dose X irradiation of Drosophila spermatocytes at a low dose rate.
|
| Journal |
Radiat Res
|
| Abstract |
A sex-linked recessive lethal mutation assay was performed in Drosophila melanogaster using immature spermatocytes and spermatogonia irradiated with X rays at a high or low dose rate. The mutation frequency in the sperm irradiated with a low dose at a low dose rate was significantly lower than that in the sham-irradiated group, whereas irradiation with a high dose resulted in a significant increase in the mutation frequency. It was obvious that the dose-response relationship was not linear, but rather was U-shaped. When mutant germ cells defective in DNA excision repair were used instead of wild-type cells, low-dose irradiation at a low dose rate did not reduce the mutation frequency. These observations suggest that error-free DNA repair functions were activated by low dose of low-dose-rate radiation and that this repaired spontaneous DNA damage rather than the X-ray-induced damage, thus producing a practical threshold.
|
| Volume |
167(2)
|
| Pages |
217-21
|
| Published |
2007-2-1
|
| DOI |
10.1667/rr0705.1
|
| PMID |
17390729
|
| MeSH |
Animals
Chromosome Mapping
Crosses, Genetic
DNA Damage
DNA Repair
Dose-Response Relationship, Radiation
Drosophila / genetics*
Drosophila / radiation effects*
Female
Genes, Recessive
Male
Mutation*
Spermatocytes / radiation effects*
Spermatozoa / radiation effects*
X-Rays*
|
| IF |
2.657
|
| Times Cited |
29
|
|
WOS Category
|
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
BIOLOGY
BIOPHYSICS
|
| Resource |
| Drosophila |
|
