論文 - 詳細
| RRC ID | 11603 |
|---|---|
| 著者 | Sakurai KT, Kojima T, Aigaki T, Hayashi S. |
| タイトル | Differential control of cell affinity required for progression and refinement of cell boundary during Drosophila leg segmentation. |
| ジャーナル | Dev Biol |
| Abstract |
Domain boundary formation in development involves sorting of different types of cells into separate spatial domains. The segment boundary between tarsus 5 (Ta5) and the pretarsus (Pre) of the Drosophila leg initially appears at the center of the leg disc and progressively sharpens and expands to its final position, accompanied by down-regulation of the cell recognition molecule Capricious and Tartan and cell displacement from Ta5 to Pre across the boundary. Capricious and Tartan are controlled by transcription factor Bar and Al, and their loss of function leads to reduction of cell affinity to wild type neighbors and cell displacement activities. In addition, although the mutant cells formed Ta5/Pre boundary, its progression and sharpening were compromised. Cells overexpressing Capricious or Tartan became invasive within Ta5 and Pre, sometimes escaping the compartmental restriction of cell movement. Dynamic spatiotemporal regulation of cell affinity mediated by Capricious and Tartan is a key property of refinement of the Ta5/Pre boundary. |
| 巻・号 | 309(1) |
| ページ | 126-36 |
| 公開日 | 2007-9-1 |
| DOI | 10.1016/j.ydbio.2007.07.001 |
| PII | S0012-1606(07)01162-1 |
| PMID | 17655839 |
| MeSH | Animals Antigens, Differentiation / metabolism Body Patterning / physiology Cell Lineage / physiology* Drosophila / growth & development Drosophila / physiology* Drosophila Proteins / genetics Drosophila Proteins / metabolism* Extremities / growth & development* Larva Membrane Proteins / genetics Membrane Proteins / metabolism* Mutation |
| IF | 2.896 |
| 引用数 | 17 |
| WOS 分野 | DEVELOPMENTAL BIOLOGY |
| リソース情報 | |
| ショウジョウバエ | DGRC#104443 |