論文 - 詳細
| RRC ID | 11630 |
|---|---|
| 著者 | Stramer B, Winfield M, Shaw T, Millard TH, Woolner S, Martin P. |
| タイトル | Gene induction following wounding of wild-type versus macrophage-deficient Drosophila embryos. |
| ジャーナル | EMBO Rep |
| Abstract |
By using a microarray screen to compare gene responses after sterile laser wounding of wild-type and 'macrophageless' serpent mutant Drosophila embryos, we show the wound-induced programmes that are independent of a pathogenic response and distinguish which of the genes are macrophage dependent. The evolutionarily conserved nature of this response is highlighted by our finding that one such new inflammation-associated gene, growth arrest and DNA damage-inducible gene 45 (GADD45), is upregulated in both Drosophila and murine repair models. Comparison of unwounded wild-type and serpent mutant embryos also shows a portfolio of 'macrophage-specific' genes, which suggest analogous functions with vertebrate inflammatory cells. Besides identifying the various classes of wound- and macrophage-related genes, our data indicate that sterile injury per se, in the absence of pathogens, triggers induction of a 'pathogen response', which might prime the organism for what is likely to be an increased risk of infection. |
| 巻・号 | 9(5) |
| ページ | 465-71 |
| 公開日 | 2008-5-1 |
| DOI | 10.1038/embor.2008.34 |
| PII | embor200834 |
| PMID | 18344972 |
| PMC | PMC2373367 |
| MeSH | Animals Drosophila / embryology* Drosophila / genetics Drosophila Proteins / physiology Embryo, Nonmammalian GATA Transcription Factors / physiology Gene Expression* Green Fluorescent Proteins / metabolism Hemocytes / physiology Homozygote Intracellular Signaling Peptides and Proteins / genetics* Intracellular Signaling Peptides and Proteins / metabolism Macrophages / physiology* Mutation Oligonucleotide Array Sequence Analysis Up-Regulation Wounds and Injuries / etiology Wounds and Injuries / genetics |
| IF | 7.497 |
| 引用数 | 40 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | F1000Research |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | GADD45 enhancer trap (DGRC#103594) |